Pathogenesis and clinical features of alopecia in epidermolysis bullosa: A systematic review

• Published in: Pediatric dermatology 2019-07, Vol.36 (4), p.430-436
• Main Authors: Xie, Danica, Bilgic‐Temel, Asli, Abu Alrub, Nada, Murrell, Dedee F.
• Format: Article
• Language: English
• Subjects: Adult; Alopecia; Alopecia Areata - epidemiology; Alopecia Areata - physiopathology; Biopsy; Comorbidity; Epidermolysis bullosa; Epidermolysis Bullosa Simplex - epidemiology; Epidermolysis Bullosa Simplex - physiopathology; Evidence-based medicine; Female; Follicles; Hair; Hair loss; Humans; Male; Pathogenesis; Prognosis; Risk Assessment; Scalp; Severity of Illness Index; Skin diseases; Systematic review; Trauma
• ISSN: 0736-8046; 1525-1470
• DOI: 10.1111/pde.13866

Background Epidermolysis bullosa (EB) is a group of rare genetic skin diseases characterized by the gene mutations encoding adhesion proteins within the skin. These adhesion proteins are also present in normal hair follicles. Anecdotally, there have been reports of scalp alopecia as a complication of EB and there are scattered cases in the literature, but alopecia has generally been overlooked in severe blistering diseases because it is regarded as a cosmetic issue. Therefore, there is no consensus about the natural history and clinical manifestations of alopecia in EB to allow potential intervention. Objectives To review the current literature detailing the pathogenesis and clinical presentations of alopecia in EB patients. Methods Relevant human studies were searched in Medline, PubMed, and EMBASE electronic databases up to October 2018. Results Only 15 reports detailed 29 EB patients with demographic and clinical manifestations of alopecia. Vertical biopsy sections were the most common method of alopecia diagnosis, and the most common pattern was patchy scalp alopecia (45%) followed by diffuse alopecia (41%). The most robust finding was nonspecific scarring alopecia in all dystrophic EB (DEB) patients and nonspecific nonscarring alopecia in most patients with EB simplex (EBS). Conclusions Hair abnormalities observed in EB are of variable severity despite there being no universal validated alopecia scoring system, with alopecia occurring secondary to blistering, or in areas prone to trauma.