Current issues regarding the application of recombinant lactic acid bacteria to mucosal vaccine carriers

Over the past two decades, lactic acid bacteria (LAB) have been intensively studied as potential bacterial carriers for therapeutic materials, such as vaccine antigens, to the mucosal tissues. LAB have several attractive advantages as carriers of mucosal vaccines, and the effectiveness of LAB vaccin...

Full description

Saved in:
Bibliographic Details
Published in:Applied microbiology and biotechnology 2019-08, Vol.103 (15), p.5947-5955
Main Authors: Takahashi, Keita, Orito, Nozomi, Tokunoh, Nagisa, Inoue, Naoki
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Bacteria
Biomedical and Life Sciences
Biotechnology
Cell-mediated immunity
Computer memory
Contamination
Health aspects
Immune response
Immunity
Immunological memory
Immunology
Lactic acid
Lactic acid bacteria
Life Sciences
Medical research
Medicine, Experimental
Memory (Computers)
Memory cells
Microbial Genetics and Genomics
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Mini-Review
Mucosa
Vaccine development
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c586t-6b9a57ab8a0417a9c501929c3efda89d85a8dd143ce52f798a346889efebd2f83
cites cdi_FETCH-LOGICAL-c586t-6b9a57ab8a0417a9c501929c3efda89d85a8dd143ce52f798a346889efebd2f83
container_end_page 5955
container_issue 15
container_start_page 5947
container_title Applied microbiology and biotechnology
container_volume 103
creator Takahashi, Keita
Orito, Nozomi
Tokunoh, Nagisa
Inoue, Naoki
description Over the past two decades, lactic acid bacteria (LAB) have been intensively studied as potential bacterial carriers for therapeutic materials, such as vaccine antigens, to the mucosal tissues. LAB have several attractive advantages as carriers of mucosal vaccines, and the effectiveness of LAB vaccines has been demonstrated in numerous studies. Research on LAB vaccines to date has focused on whether antigen-specific immunity, particularly antibody responses, can be induced. However, with recent developments in immunology, microbiology, and vaccinology, more detailed analyses of the underlying mechanisms, especially, of the induction of cell-mediated immunity and memory cells, have been required for vaccine development and licensure. In this mini-review, we will discuss the issues, including (i) immune responses other than antibody production, (ii) persistence of LAB vaccine immunity, (iii) comparative evaluation of LAB vaccines with any existing or reference vaccines, (iv) strategies for increasing the effectiveness of LAB vaccines, and (iv) effects of microbiota on the efficacy of LAB vaccines. Although these issues have been rarely studied or discussed to date in relation to LAB vaccine research, further understanding of them is critical for the practical application of LAB vaccine systems.
doi_str_mv 10.1007/s00253-019-09912-x
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2255461725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A592821591</galeid><sourcerecordid>A592821591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c586t-6b9a57ab8a0417a9c501929c3efda89d85a8dd143ce52f798a346889efebd2f83</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EosvCH-CALHGBQ4o_4sQ-Vis-KlVC4uNsTZxJ6iqxFztBy7_HZUvRIoR8sOV53hm_4yHkOWfnnLH2TWZMKFkxbipmDBfV4QHZ8FqKijW8fkg2jLeqapXRZ-RJzjeMcaGb5jE5k7xEask35Hq3poRhoT7nFTNNOELqfRjpco0U9vvJO1h8DDQOJeji3PkAhZ_ALd5RcL6nXTlj8kCXSOfVxQwT_Q7O-YDUQUoeU35KHg0wZXx2t2_J13dvv-w-VFcf31_uLq4qp3SzVE1nQLXQaWA1b8E4VewJ4yQOPWjTawW674tJh0oMrdEg60ZrgwN2vRi03JJXx7z7FL8VR4udfXY4TRAwrtkKoVTd8LZ0bkte_oXexDWF8rpCyUbKRpRC99QIE1ofhrgkcLdJ7YUyQguuDC_U-T-osnqcvYsBB1_uTwSvTwSFWfCwjLDmbC8_fzplxZF1KeaccLD75GdIPyxn9nYU7HEUbOmV_TUK9lBEL-7crd2M_b3k998XQB6BXEJhxPTH_n_S_gSEUL3T</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2236336214</pqid></control><display><type>article</type><title>Current issues regarding the application of recombinant lactic acid bacteria to mucosal vaccine carriers</title><source>ABI/INFORM Global</source><source>Springer Link</source><creator>Takahashi, Keita ; Orito, Nozomi ; Tokunoh, Nagisa ; Inoue, Naoki</creator><creatorcontrib>Takahashi, Keita ; Orito, Nozomi ; Tokunoh, Nagisa ; Inoue, Naoki</creatorcontrib><description>Over the past two decades, lactic acid bacteria (LAB) have been intensively studied as potential bacterial carriers for therapeutic materials, such as vaccine antigens, to the mucosal tissues. LAB have several attractive advantages as carriers of mucosal vaccines, and the effectiveness of LAB vaccines has been demonstrated in numerous studies. Research on LAB vaccines to date has focused on whether antigen-specific immunity, particularly antibody responses, can be induced. However, with recent developments in immunology, microbiology, and vaccinology, more detailed analyses of the underlying mechanisms, especially, of the induction of cell-mediated immunity and memory cells, have been required for vaccine development and licensure. In this mini-review, we will discuss the issues, including (i) immune responses other than antibody production, (ii) persistence of LAB vaccine immunity, (iii) comparative evaluation of LAB vaccines with any existing or reference vaccines, (iv) strategies for increasing the effectiveness of LAB vaccines, and (iv) effects of microbiota on the efficacy of LAB vaccines. Although these issues have been rarely studied or discussed to date in relation to LAB vaccine research, further understanding of them is critical for the practical application of LAB vaccine systems.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-019-09912-x</identifier><identifier>PMID: 31175431</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antibodies ; Antigens ; Bacteria ; Biomedical and Life Sciences ; Biotechnology ; Cell-mediated immunity ; Computer memory ; Contamination ; Health aspects ; Immune response ; Immunity ; Immunological memory ; Immunology ; Lactic acid ; Lactic acid bacteria ; Life Sciences ; Medical research ; Medicine, Experimental ; Memory (Computers) ; Memory cells ; Microbial Genetics and Genomics ; Microbiology ; Microbiota ; Microbiota (Symbiotic organisms) ; Mini-Review ; Mucosa ; Vaccine development ; Vaccines</subject><ispartof>Applied microbiology and biotechnology, 2019-08, Vol.103 (15), p.5947-5955</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Applied Microbiology and Biotechnology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-6b9a57ab8a0417a9c501929c3efda89d85a8dd143ce52f798a346889efebd2f83</citedby><cites>FETCH-LOGICAL-c586t-6b9a57ab8a0417a9c501929c3efda89d85a8dd143ce52f798a346889efebd2f83</cites><orcidid>0000-0002-0859-6449</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2236336214/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2236336214?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,11667,27901,27902,36037,36038,44339,74638</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31175431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Keita</creatorcontrib><creatorcontrib>Orito, Nozomi</creatorcontrib><creatorcontrib>Tokunoh, Nagisa</creatorcontrib><creatorcontrib>Inoue, Naoki</creatorcontrib><title>Current issues regarding the application of recombinant lactic acid bacteria to mucosal vaccine carriers</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Over the past two decades, lactic acid bacteria (LAB) have been intensively studied as potential bacterial carriers for therapeutic materials, such as vaccine antigens, to the mucosal tissues. LAB have several attractive advantages as carriers of mucosal vaccines, and the effectiveness of LAB vaccines has been demonstrated in numerous studies. Research on LAB vaccines to date has focused on whether antigen-specific immunity, particularly antibody responses, can be induced. However, with recent developments in immunology, microbiology, and vaccinology, more detailed analyses of the underlying mechanisms, especially, of the induction of cell-mediated immunity and memory cells, have been required for vaccine development and licensure. In this mini-review, we will discuss the issues, including (i) immune responses other than antibody production, (ii) persistence of LAB vaccine immunity, (iii) comparative evaluation of LAB vaccines with any existing or reference vaccines, (iv) strategies for increasing the effectiveness of LAB vaccines, and (iv) effects of microbiota on the efficacy of LAB vaccines. Although these issues have been rarely studied or discussed to date in relation to LAB vaccine research, further understanding of them is critical for the practical application of LAB vaccine systems.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Bacteria</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cell-mediated immunity</subject><subject>Computer memory</subject><subject>Contamination</subject><subject>Health aspects</subject><subject>Immune response</subject><subject>Immunity</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Lactic acid</subject><subject>Lactic acid bacteria</subject><subject>Life Sciences</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Memory (Computers)</subject><subject>Memory cells</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Mini-Review</subject><subject>Mucosa</subject><subject>Vaccine development</subject><subject>Vaccines</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNp9kk1v1DAQhi0EosvCH-CALHGBQ4o_4sQ-Vis-KlVC4uNsTZxJ6iqxFztBy7_HZUvRIoR8sOV53hm_4yHkOWfnnLH2TWZMKFkxbipmDBfV4QHZ8FqKijW8fkg2jLeqapXRZ-RJzjeMcaGb5jE5k7xEask35Hq3poRhoT7nFTNNOELqfRjpco0U9vvJO1h8DDQOJeji3PkAhZ_ALd5RcL6nXTlj8kCXSOfVxQwT_Q7O-YDUQUoeU35KHg0wZXx2t2_J13dvv-w-VFcf31_uLq4qp3SzVE1nQLXQaWA1b8E4VewJ4yQOPWjTawW674tJh0oMrdEg60ZrgwN2vRi03JJXx7z7FL8VR4udfXY4TRAwrtkKoVTd8LZ0bkte_oXexDWF8rpCyUbKRpRC99QIE1ofhrgkcLdJ7YUyQguuDC_U-T-osnqcvYsBB1_uTwSvTwSFWfCwjLDmbC8_fzplxZF1KeaccLD75GdIPyxn9nYU7HEUbOmV_TUK9lBEL-7crd2M_b3k998XQB6BXEJhxPTH_n_S_gSEUL3T</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Takahashi, Keita</creator><creator>Orito, Nozomi</creator><creator>Tokunoh, Nagisa</creator><creator>Inoue, Naoki</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0859-6449</orcidid></search><sort><creationdate>20190801</creationdate><title>Current issues regarding the application of recombinant lactic acid bacteria to mucosal vaccine carriers</title><author>Takahashi, Keita ; Orito, Nozomi ; Tokunoh, Nagisa ; Inoue, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-6b9a57ab8a0417a9c501929c3efda89d85a8dd143ce52f798a346889efebd2f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antibodies</topic><topic>Antigens</topic><topic>Bacteria</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cell-mediated immunity</topic><topic>Computer memory</topic><topic>Contamination</topic><topic>Health aspects</topic><topic>Immune response</topic><topic>Immunity</topic><topic>Immunological memory</topic><topic>Immunology</topic><topic>Lactic acid</topic><topic>Lactic acid bacteria</topic><topic>Life Sciences</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Memory (Computers)</topic><topic>Memory cells</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Mini-Review</topic><topic>Mucosa</topic><topic>Vaccine development</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Keita</creatorcontrib><creatorcontrib>Orito, Nozomi</creatorcontrib><creatorcontrib>Tokunoh, Nagisa</creatorcontrib><creatorcontrib>Inoue, Naoki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>Biological Sciences</collection><collection>ABI/INFORM Global</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Keita</au><au>Orito, Nozomi</au><au>Tokunoh, Nagisa</au><au>Inoue, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current issues regarding the application of recombinant lactic acid bacteria to mucosal vaccine carriers</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>103</volume><issue>15</issue><spage>5947</spage><epage>5955</epage><pages>5947-5955</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Over the past two decades, lactic acid bacteria (LAB) have been intensively studied as potential bacterial carriers for therapeutic materials, such as vaccine antigens, to the mucosal tissues. LAB have several attractive advantages as carriers of mucosal vaccines, and the effectiveness of LAB vaccines has been demonstrated in numerous studies. Research on LAB vaccines to date has focused on whether antigen-specific immunity, particularly antibody responses, can be induced. However, with recent developments in immunology, microbiology, and vaccinology, more detailed analyses of the underlying mechanisms, especially, of the induction of cell-mediated immunity and memory cells, have been required for vaccine development and licensure. In this mini-review, we will discuss the issues, including (i) immune responses other than antibody production, (ii) persistence of LAB vaccine immunity, (iii) comparative evaluation of LAB vaccines with any existing or reference vaccines, (iv) strategies for increasing the effectiveness of LAB vaccines, and (iv) effects of microbiota on the efficacy of LAB vaccines. Although these issues have been rarely studied or discussed to date in relation to LAB vaccine research, further understanding of them is critical for the practical application of LAB vaccine systems.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31175431</pmid><doi>10.1007/s00253-019-09912-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0859-6449</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0175-7598
ispartof Applied microbiology and biotechnology, 2019-08, Vol.103 (15), p.5947-5955
issn 0175-7598
1432-0614
language eng
recordid cdi_proquest_miscellaneous_2255461725
source ABI/INFORM Global; Springer Link
subjects Antibodies
Antigens
Bacteria
Biomedical and Life Sciences
Biotechnology
Cell-mediated immunity
Computer memory
Contamination
Health aspects
Immune response
Immunity
Immunological memory
Immunology
Lactic acid
Lactic acid bacteria
Life Sciences
Medical research
Medicine, Experimental
Memory (Computers)
Memory cells
Microbial Genetics and Genomics
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Mini-Review
Mucosa
Vaccine development
Vaccines
title Current issues regarding the application of recombinant lactic acid bacteria to mucosal vaccine carriers
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T17%3A44%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Current%20issues%20regarding%20the%20application%20of%20recombinant%20lactic%20acid%20bacteria%20to%20mucosal%20vaccine%20carriers&rft.jtitle=Applied%20microbiology%20and%20biotechnology&rft.au=Takahashi,%20Keita&rft.date=2019-08-01&rft.volume=103&rft.issue=15&rft.spage=5947&rft.epage=5955&rft.pages=5947-5955&rft.issn=0175-7598&rft.eissn=1432-0614&rft_id=info:doi/10.1007/s00253-019-09912-x&rft_dat=%3Cgale_proqu%3EA592821591%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c586t-6b9a57ab8a0417a9c501929c3efda89d85a8dd143ce52f798a346889efebd2f83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2236336214&rft_id=info:pmid/31175431&rft_galeid=A592821591&rfr_iscdi=true