Multi-spectral laser speckle contrast images using a wavelength-swept laser

A multi-spectral laser speckle contrast imaging (MS-LSCI) system is proposed using only a single wavelength-swept laser, which provides both highly coherent and multi-spectral outputs to simultaneously generate laser speckle contrast images and multi-spectral images, respectively. Using a laser ligh...

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Bibliographic Details
Published in:Journal of biomedical optics 2019-07, Vol.24 (7), p.076001-076001
Main Authors: Kim, Jeong Won, Jang, Hansol, Kim, Gyeong Hun, Jun, Seung Won, Kim, Chang-Seok
Format: Article
Language:English
Subjects:
Cameras
CCD cameras
CMOS
Experiments
Flow velocity
Hemodynamics
Image acquisition
Image contrast
Imaging
Ischemia
Lasers
Light
Light sources
Oxygen content
Sensors
Wavelength
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Summary:A multi-spectral laser speckle contrast imaging (MS-LSCI) system is proposed using only a single wavelength-swept laser, which provides both highly coherent and multi-spectral outputs to simultaneously generate laser speckle contrast images and multi-spectral images, respectively. Using a laser light swept from 770 to 821 nm at a repetition rate of 5 Hz and a CCD camera of 335 fps, 67 multi-spectral frame images are acquired in 0.76 nm wavebands over 51 nm spectral range. The spectral sub-windowing method of single wavelength-swept laser source is used to solve the lack of spectral information from a few individual light sources, which is a limitation of conventional MS-LSCI systems. In addition to the speckle flow index from the LSCI frames, the multi-spectrally encoded images can generate additional images of spectral absorbance. To further examine the performance of the MS-LSCI system, an in vivo cuff-induced ischemia experiment was conducted to show the real-time imaging of hemodynamic and blood oxygen saturation changes simultaneously over the entire 2.5  cm  ×  4.5  cm field of view.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.24.7.076001