MicroRNA targeting by quercetin in cancer treatment and chemoprotection

[Display omitted] A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural produ...

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Published in:Pharmacological research 2019-09, Vol.147, p.104346-104346, Article 104346
Main Authors: Kim, Doo Hwan, Khan, Haroon, Ullah, Hammad, Hassan, Sherif T.S., Šmejkal, Karel, Efferth, Thomas, Mahomoodally, Mohamad Fawzi, Xu, Suowen, Habtemariam, Solomon, Filosa, Rosanna, Lagoa, Ricardo, Rengasamy, Kannan RR
Format: Article
Language:English
Subjects:
Bioinformatic tools
Cancer
Carcinogenesis
Chemoprevention
Epigenetic regulation
Flavonoids
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Summary:[Display omitted] A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer properties due to their proven antioxidant, anti-inflammatory, and anti-proliferative effects. Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development. This paper reviews the data supporting the use of quercetin for miRNA-mediated chemopreventive and therapeutic strategies in various cancers, with the aim to comprehensively understand its health‐promoting benefits and pharmacological potential. Integration of technology platforms for miRNAs biomarker and drug discovery is also presented.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2019.104346