The Impact of HIV-1 Drug Escape on the Global Treatment Landscape

The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in combating the HIV epidemic and compromise the 90-90-90 target proposed by United Nations Programme on HIV/AIDS (UNAIDS) to have achieved virological suppression in 90% of all persons receiving antiretroviral therapy (A...

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Bibliographic Details
Published in:Cell host & microbe 2019-07, Vol.26 (1), p.48-60
Main Authors: Collier, D.A., Monit, C., Gupta, R.K.
Format: Article
Language:English
Subjects:
antiretroviral
drug
HIV
mechanism
resistance
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Summary:The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in combating the HIV epidemic and compromise the 90-90-90 target proposed by United Nations Programme on HIV/AIDS (UNAIDS) to have achieved virological suppression in 90% of all persons receiving antiretroviral therapy (ART) by the year 2020. HIVDR has implications for the persistence of HIV, the selection of current and future ART drug regimens, and strategies of vaccine and cure development. Focusing on drug classes that are in clinical use, this Review critically summarizes what is known about the mechanisms the virus utilizes to escape drug control. Armed with this knowledge, strategies to limit the expansion of HIVDR are proposed. HIV drug resistance has implications for viral persistence, the selection of ART drug regimens, and vaccine and cure development. In this Review, Collier et al. summarize the state of global HIV resistance, mechanisms that HIV utilizes to escape drug control, and the implications for future antiretroviral therapies.
ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2019.06.010