Influence of a polymer membrane on the electrochemical determination of insulin in nanomodified screen printed carbon electrodes

Diabetes mellitus can be considered one of the most widespread diseases globally. Hence, the diabetes research is currently focused on developing an effective, low-cost sensor having high stability and suitable analytical characteristics. Screen printed carbon electrodes (SPCEs) embody ideal candida...

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Published in:Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2019-12, Vol.130, p.107326-107326, Article 107326
Main Authors: Šišoláková, Ivana, Hovancová, Jana, Oriňaková, Renáta, Oriňak, Andrej, Trnková, Libuše, García, Daniel Rueda, Radoňak, Jozef
Format: Article
Language:English
Subjects:
Chitosan
Cost analysis
Diabetes
Diabetes mellitus
Electrochemistry
Electrodes
Insulin
Mathematical analysis
Membranes
Multi wall carbon nanotubes
Nanoparticles
Polymers
Sensors
Stability analysis
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Summary:Diabetes mellitus can be considered one of the most widespread diseases globally. Hence, the diabetes research is currently focused on developing an effective, low-cost sensor having high stability and suitable analytical characteristics. Screen printed carbon electrodes (SPCEs) embody ideal candidates for insulin determination due to the small area of the working electrode eliminating the solution volume required for the given purpose. Modification of SPCEs by using nanoparticles resulted in an increase of the working electrode surface area and formation of a higher number of active species. The aim of this paper is to examine the impact of a chitosan membrane on the electrochemical determination of insulin on NiO nanoparticles (NiONPs) and multi-walled nanotube (MWCNTs) modified SPCE (NiONPs/MWCNTs/SPCE). This study is primarily conceived to compare the analytical characteristics and stability of NiONPs/chitosan-MWCNTs/SPCE and NiONPs/MWCNTs/SPCE. An electrode modified with chitosan displays a wider linear range, one of 0.25 μM - 5 μM (R 0.997); a lower limit of detection, 94 nM; a high sensitivity (0.021 μA/μM) and better stability than that of an electrode without chitosan. According to these characteristics, the polymer is considered a necessary compound of the electrochemical insulin sensor, improving the sensor's analytical characteristics.
ISSN:1567-5394
1878-562X
DOI:10.1016/j.bioelechem.2019.06.011