PUVA-induced pityriasis lichenoides chronica-like papular lesions in patients with mycosis fungoides: a clinical, histopathological and immunohistochemical study

Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma (CTCL) with many clinical variants including papular and pityriasis lichenoides chronica (PLC)-like variants. During psoralen and ultraviolet A (PUVA) treatment of MF, PLC-like papular lesions were observed to appear. The ex...

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Bibliographic Details
Published in:Archives of Dermatological Research 2019-11, Vol.311 (9), p.673-678
Main Authors: Youssef, Randa, Abdel-Halim, Mona R. E., Abdel Halim, Dalia M., Fawzy, Marwa M., Hussein, Marwa F., Elmasry, Maha Fathy, Sayed, Safinaz S., Abo Eid, Noha M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
CD4 antigen
CD4 Antigens - analysis
CD8 antigen
CD8 Antigens - analysis
Cross-Sectional Studies
Dermatology
Female
Fungal infections
Humans
Immunohistochemistry
Lymphocytes T
Male
Medicine
Medicine & Public Health
Middle Aged
Mimicry
Monoclonal antibodies
Mycosis
Mycosis fungoides
Mycosis Fungoides - drug therapy
Original Paper
Patients
Photochemotherapy
Phototherapy
Pityriasis
Pityriasis Lichenoides - etiology
Pityriasis Lichenoides - pathology
Psoralen
PUVA Therapy - adverse effects
Skin - drug effects
Skin - pathology
Skin - radiation effects
Skin Neoplasms - drug therapy
T-cell lymphoma
Young Adult
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Description
Summary:Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma (CTCL) with many clinical variants including papular and pityriasis lichenoides chronica (PLC)-like variants. During psoralen and ultraviolet A (PUVA) treatment of MF, PLC-like papular lesions were observed to appear. The exact nature of these lesions is not fully understood. This work aimed to study PLC-like papular lesions arising in MF patients receiving PUVA therapy clinically, histopathologically and immunohistochemically (using monoclonal antibodies against CD4 and CD8) and to compare them with lesions in classic PLC patients. Fifteen MF patients with PLC-like papular lesions arising during PUVA treatment were included and 15 patients with classic PLC served as controls. While the extent of these lesions significantly correlated with their duration ( p  
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-019-01949-2