Brain structural differences in monozygotic twins discordant for body mass index

Substantial efforts have been made to investigate the neurobiological underpinnings of human obesity with a number of studies indicating a profound influence of increased body weight on brain structure. Although body weight is known to be highly heritable, uncertainty remains regarding the respectiv...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2019-11, Vol.201, p.116006-116006, Article 116006
Main Authors: Weise, Christopher M., Bachmann, Tobias, Pleger, Burkhard
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Body weight
Brain - pathology
Cerebellum
Environmental factors
Female
Gray Matter - pathology
Humans
Magnetic Resonance Imaging
Male
Morphometry
Neostriatum
Neuroimaging
Nucleus accumbens
Obesity
Occipital lobe
Prefrontal cortex
Siblings
Studies
Substantia grisea
Twins
Twins, Monozygotic
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Summary:Substantial efforts have been made to investigate the neurobiological underpinnings of human obesity with a number of studies indicating a profound influence of increased body weight on brain structure. Although body weight is known to be highly heritable, uncertainty remains regarding the respective contribution of genetic and environmental influences. In this study we used structural magnetic resonance imaging (MRI) data from the Human Connectome Project (HCP). Voxel-based morphometry (VBM) was applied to study BMI-associated differences in gray matter volume (GMV) within monozygotic (MZ) twin pairs discordant for BMI (ΔBMI ​> ​2.5 ​kg*m−2, n = 68 pairs). In addition, we investigated the relationship of ΔBMI (entire range) with GMV differences within the entire sample of MZ twin pairs (n = 153 pairs). Analyses of BMI discordant twin pairs yielded less GMV in heavier twin siblings (p 
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2019.07.019