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Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young men
Introduction Retrograde shear causes endothelial damage and is pro-atherogenic. The purpose of our study was to examine the impact of vascular remodeling from habitual exercise training on acute changes in retrograde shear and microvascular oxygenation (SMO 2 ) induced via 30 min of external compres...
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| Published in: | European journal of applied physiology 2019-08, Vol.119 (8), p.1809-1818 |
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| container_issue | 8 |
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| container_title | European journal of applied physiology |
| container_volume | 119 |
| creator | Lassalle, Patricia Pagan Palamar, Adam J. DeBlois, Jacob P. Lefferts, Wesley K. Heffernan, Kevin S. |
| description | Introduction
Retrograde shear causes endothelial damage and is pro-atherogenic. The purpose of our study was to examine the impact of vascular remodeling from habitual exercise training on acute changes in retrograde shear and microvascular oxygenation (SMO
2
) induced via 30 min of external compression.
Methods
Participants included 11 exercise trained (ET) men (Division I track athletes; age 20 ± 3 years) and 18 recreationally active (RA) men (age 23 ± 5 years). Near-infrared spectroscopy (NIRS) was used to measure vastus medialis SMO
2
. Doppler-ultrasound was used to assess SFA intima-media thickness, diameter and flow velocity to derive retrograde shear. Vascular measures were made at baseline (BASELINE), during a sham condition (calf compression to 5 mmHg, SHAM) and during the experimental condition (calf compression to 60 mmHg, EXP).
Results
Compared to RA, ET had larger SFA diameters (0.66 ± 0.06 vs 0.58 ± 0.06 cm,
p
|
| doi_str_mv | 10.1007/s00421-019-04170-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2258158291</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2258158291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-8815912816c04be2747ddc8239e48b1876e1f3bc3e1eae89f77150cceb00df313</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EoqXwBTggS1y4BGbs7MY5oqr8kSpxgbPlOOMlVWIv46Tqfot-ZJzdUiQOSJZsjX_vjfSeEK8R3iNA8yED1AorwLaCGhuo8Ik4x1q31Var5unjG9sz8SLnGwAwCs1zcaYRW1CozsX9VQjkZ5mCpLuZOLpR-jTtmXIeUpTlBJoSlzHTzGnHrieZf5Jj6WIvp8FzunXZL2OZpLvDjqKbV-UQiyOxHzLJmd0QqT8qmDzTEXHjeJDOz8MtyUNa4k5OFF-KZ8GNmV493Bfix6er75dfqutvn79efryufI1mrozBTYvK4NZD3ZFq6qbvvVG6pdp0aJotYdCd14TkyLShaXAD3lMH0AeN-kK8O_nuOf1aKM92GrKncXSR0pKtUpuywqh2Rd_-g96kZU1qpbQpmSpjCqVOVAkkZ6Zg9zxMjg8Wwa592VNftvRlj33Z1frNg_XSTdQ_Sv4UVAB9AnL5ijviv7v_Y_sb-iii-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2238821288</pqid></control><display><type>article</type><title>Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young men</title><source>Springer Link</source><creator>Lassalle, Patricia Pagan ; Palamar, Adam J. ; DeBlois, Jacob P. ; Lefferts, Wesley K. ; Heffernan, Kevin S.</creator><creatorcontrib>Lassalle, Patricia Pagan ; Palamar, Adam J. ; DeBlois, Jacob P. ; Lefferts, Wesley K. ; Heffernan, Kevin S.</creatorcontrib><description>Introduction
Retrograde shear causes endothelial damage and is pro-atherogenic. The purpose of our study was to examine the impact of vascular remodeling from habitual exercise training on acute changes in retrograde shear and microvascular oxygenation (SMO
2
) induced via 30 min of external compression.
Methods
Participants included 11 exercise trained (ET) men (Division I track athletes; age 20 ± 3 years) and 18 recreationally active (RA) men (age 23 ± 5 years). Near-infrared spectroscopy (NIRS) was used to measure vastus medialis SMO
2
. Doppler-ultrasound was used to assess SFA intima-media thickness, diameter and flow velocity to derive retrograde shear. Vascular measures were made at baseline (BASELINE), during a sham condition (calf compression to 5 mmHg, SHAM) and during the experimental condition (calf compression to 60 mmHg, EXP).
Results
Compared to RA, ET had larger SFA diameters (0.66 ± 0.06 vs 0.58 ± 0.06 cm,
p
< 0.05) and lower SFA IMT (0.33 ± 0.03 vs 0.36 ± 0.07 mm,
p
< 0.05). Retrograde shear increased similarly in both groups during EXP (
p
< 0.05) but ET men had lower overall retrograde shear during the conditions (BASELINE 75.8 ± 26.8 vs EXP 88.2 ± 16.9 s
−1
) compared to RA men (BASELINE 84.4 ± 23.3 vs EXP 106.4 ± 19.6 s
−1
p
< 0.05). There was a similar increase in SMO
2
from BASELINE to SHAM (ET + 8.1 ± 4.8 vs RA + 6.4 ± 9.7%) and BASELINE to EXP (ET + 8.7 ± 6.4 vs RA + 7.1 ± 9.0%) in both groups.
Conclusion
Beneficial vascular remodeling in ET men is associated with lower retrograde shear during external compression. Acute increases in retrograde shear with external compression do not detrimentally impact microvascular oxygenation.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-019-04170-1</identifier><identifier>PMID: 31190212</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Biomedical and Life Sciences ; Biomedicine ; Compression ; Compression Bandages ; Doppler effect ; Endothelium, Vascular - physiology ; Exercise ; Femoral Artery - physiology ; Femur ; Flow velocity ; Hemodynamics ; Human Physiology ; Humans ; Infrared spectroscopy ; Male ; Microvasculature ; Microvessels - physiology ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - physiology ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen Consumption ; Oxygenation ; Reperfusion ; Sports Medicine ; Ultrasound</subject><ispartof>European journal of applied physiology, 2019-08, Vol.119 (8), p.1809-1818</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Applied Physiology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-8815912816c04be2747ddc8239e48b1876e1f3bc3e1eae89f77150cceb00df313</citedby><cites>FETCH-LOGICAL-c418t-8815912816c04be2747ddc8239e48b1876e1f3bc3e1eae89f77150cceb00df313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31190212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lassalle, Patricia Pagan</creatorcontrib><creatorcontrib>Palamar, Adam J.</creatorcontrib><creatorcontrib>DeBlois, Jacob P.</creatorcontrib><creatorcontrib>Lefferts, Wesley K.</creatorcontrib><creatorcontrib>Heffernan, Kevin S.</creatorcontrib><title>Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young men</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Introduction
Retrograde shear causes endothelial damage and is pro-atherogenic. The purpose of our study was to examine the impact of vascular remodeling from habitual exercise training on acute changes in retrograde shear and microvascular oxygenation (SMO
2
) induced via 30 min of external compression.
Methods
Participants included 11 exercise trained (ET) men (Division I track athletes; age 20 ± 3 years) and 18 recreationally active (RA) men (age 23 ± 5 years). Near-infrared spectroscopy (NIRS) was used to measure vastus medialis SMO
2
. Doppler-ultrasound was used to assess SFA intima-media thickness, diameter and flow velocity to derive retrograde shear. Vascular measures were made at baseline (BASELINE), during a sham condition (calf compression to 5 mmHg, SHAM) and during the experimental condition (calf compression to 60 mmHg, EXP).
Results
Compared to RA, ET had larger SFA diameters (0.66 ± 0.06 vs 0.58 ± 0.06 cm,
p
< 0.05) and lower SFA IMT (0.33 ± 0.03 vs 0.36 ± 0.07 mm,
p
< 0.05). Retrograde shear increased similarly in both groups during EXP (
p
< 0.05) but ET men had lower overall retrograde shear during the conditions (BASELINE 75.8 ± 26.8 vs EXP 88.2 ± 16.9 s
−1
) compared to RA men (BASELINE 84.4 ± 23.3 vs EXP 106.4 ± 19.6 s
−1
p
< 0.05). There was a similar increase in SMO
2
from BASELINE to SHAM (ET + 8.1 ± 4.8 vs RA + 6.4 ± 9.7%) and BASELINE to EXP (ET + 8.7 ± 6.4 vs RA + 7.1 ± 9.0%) in both groups.
Conclusion
Beneficial vascular remodeling in ET men is associated with lower retrograde shear during external compression. Acute increases in retrograde shear with external compression do not detrimentally impact microvascular oxygenation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Compression</subject><subject>Compression Bandages</subject><subject>Doppler effect</subject><subject>Endothelium, Vascular - physiology</subject><subject>Exercise</subject><subject>Femoral Artery - physiology</subject><subject>Femur</subject><subject>Flow velocity</subject><subject>Hemodynamics</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Infrared spectroscopy</subject><subject>Male</subject><subject>Microvasculature</subject><subject>Microvessels - physiology</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - physiology</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Oxygen Consumption</subject><subject>Oxygenation</subject><subject>Reperfusion</subject><subject>Sports Medicine</subject><subject>Ultrasound</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v1DAQxS0EoqXwBTggS1y4BGbs7MY5oqr8kSpxgbPlOOMlVWIv46Tqfot-ZJzdUiQOSJZsjX_vjfSeEK8R3iNA8yED1AorwLaCGhuo8Ik4x1q31Var5unjG9sz8SLnGwAwCs1zcaYRW1CozsX9VQjkZ5mCpLuZOLpR-jTtmXIeUpTlBJoSlzHTzGnHrieZf5Jj6WIvp8FzunXZL2OZpLvDjqKbV-UQiyOxHzLJmd0QqT8qmDzTEXHjeJDOz8MtyUNa4k5OFF-KZ8GNmV493Bfix6er75dfqutvn79efryufI1mrozBTYvK4NZD3ZFq6qbvvVG6pdp0aJotYdCd14TkyLShaXAD3lMH0AeN-kK8O_nuOf1aKM92GrKncXSR0pKtUpuywqh2Rd_-g96kZU1qpbQpmSpjCqVOVAkkZ6Zg9zxMjg8Wwa592VNftvRlj33Z1frNg_XSTdQ_Sv4UVAB9AnL5ijviv7v_Y_sb-iii-g</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Lassalle, Patricia Pagan</creator><creator>Palamar, Adam J.</creator><creator>DeBlois, Jacob P.</creator><creator>Lefferts, Wesley K.</creator><creator>Heffernan, Kevin S.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190801</creationdate><title>Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young men</title><author>Lassalle, Patricia Pagan ; Palamar, Adam J. ; DeBlois, Jacob P. ; Lefferts, Wesley K. ; Heffernan, Kevin S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-8815912816c04be2747ddc8239e48b1876e1f3bc3e1eae89f77150cceb00df313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Compression</topic><topic>Compression Bandages</topic><topic>Doppler effect</topic><topic>Endothelium, Vascular - physiology</topic><topic>Exercise</topic><topic>Femoral Artery - physiology</topic><topic>Femur</topic><topic>Flow velocity</topic><topic>Hemodynamics</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Infrared spectroscopy</topic><topic>Male</topic><topic>Microvasculature</topic><topic>Microvessels - physiology</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - physiology</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Oxygen Consumption</topic><topic>Oxygenation</topic><topic>Reperfusion</topic><topic>Sports Medicine</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lassalle, Patricia Pagan</creatorcontrib><creatorcontrib>Palamar, Adam J.</creatorcontrib><creatorcontrib>DeBlois, Jacob P.</creatorcontrib><creatorcontrib>Lefferts, Wesley K.</creatorcontrib><creatorcontrib>Heffernan, Kevin S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lassalle, Patricia Pagan</au><au>Palamar, Adam J.</au><au>DeBlois, Jacob P.</au><au>Lefferts, Wesley K.</au><au>Heffernan, Kevin S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young men</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>119</volume><issue>8</issue><spage>1809</spage><epage>1818</epage><pages>1809-1818</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Introduction
Retrograde shear causes endothelial damage and is pro-atherogenic. The purpose of our study was to examine the impact of vascular remodeling from habitual exercise training on acute changes in retrograde shear and microvascular oxygenation (SMO
2
) induced via 30 min of external compression.
Methods
Participants included 11 exercise trained (ET) men (Division I track athletes; age 20 ± 3 years) and 18 recreationally active (RA) men (age 23 ± 5 years). Near-infrared spectroscopy (NIRS) was used to measure vastus medialis SMO
2
. Doppler-ultrasound was used to assess SFA intima-media thickness, diameter and flow velocity to derive retrograde shear. Vascular measures were made at baseline (BASELINE), during a sham condition (calf compression to 5 mmHg, SHAM) and during the experimental condition (calf compression to 60 mmHg, EXP).
Results
Compared to RA, ET had larger SFA diameters (0.66 ± 0.06 vs 0.58 ± 0.06 cm,
p
< 0.05) and lower SFA IMT (0.33 ± 0.03 vs 0.36 ± 0.07 mm,
p
< 0.05). Retrograde shear increased similarly in both groups during EXP (
p
< 0.05) but ET men had lower overall retrograde shear during the conditions (BASELINE 75.8 ± 26.8 vs EXP 88.2 ± 16.9 s
−1
) compared to RA men (BASELINE 84.4 ± 23.3 vs EXP 106.4 ± 19.6 s
−1
p
< 0.05). There was a similar increase in SMO
2
from BASELINE to SHAM (ET + 8.1 ± 4.8 vs RA + 6.4 ± 9.7%) and BASELINE to EXP (ET + 8.7 ± 6.4 vs RA + 7.1 ± 9.0%) in both groups.
Conclusion
Beneficial vascular remodeling in ET men is associated with lower retrograde shear during external compression. Acute increases in retrograde shear with external compression do not detrimentally impact microvascular oxygenation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31190212</pmid><doi>10.1007/s00421-019-04170-1</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Adult Biomedical and Life Sciences Biomedicine Compression Compression Bandages Doppler effect Endothelium, Vascular - physiology Exercise Femoral Artery - physiology Femur Flow velocity Hemodynamics Human Physiology Humans Infrared spectroscopy Male Microvasculature Microvessels - physiology Muscle, Skeletal - blood supply Muscle, Skeletal - physiology Occupational Medicine/Industrial Medicine Original Article Oxygen Consumption Oxygenation Reperfusion Sports Medicine Ultrasound |
| title | Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young men |
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