A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf

One new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine (1) together with four known compounds (2-5), were isolated from the fruits of Tabernaemontana inconspicua Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. Th...

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Bibliographic Details
Published in:Natural product research 2021-05, Vol.35 (10), p.1590-1595
Main Authors: Foudjo Melacheu Laura, Gertrude, Mfotie Njoya, Emmanuel, Jouda, Jean-Bosco, Wakeu Kweka, Brussine Nadege, Djama Mbazoa, Céline, Wang, Fei, Seguin, Elisabeth, Wandji, Jean
Format: Article
Language:English
Subjects:
Alkaloids
Breast cancer
cytotoxic activity
Cytotoxicity
indole alkaloids
Indoles
NMR
Nuclear magnetic resonance
Tabernaemontana
Tabernaemontana inconspicua
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Summary:One new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine (1) together with four known compounds (2-5), were isolated from the fruits of Tabernaemontana inconspicua Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. The new compound was found to be cytotoxic on human breast cancer MDA-MB 231 cells with IC 50 values of 3.35 µM and 2.19 µM after 24 and 48 hours, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1628749