PLEKHG5 is a novel prognostic biomarker in glioma patients

Background PLEKHG5, a Rho-specific guanine-nucleotide exchange factor, is involved in tumor cell migration, invasion and angiogenic potential. In this study, the expression pattern, prognostic value and function of PLEKHG5 in gliomas were investigated. Methods Immunohistochemistry was used to determ...

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Bibliographic Details
Published in:International journal of clinical oncology 2019-11, Vol.24 (11), p.1350-1358
Main Authors: Qian, Mingyu, Chen, Zihang, Wang, Shaobo, Guo, Xiaofan, Zhang, Zongpu, Qiu, Wei, Gao, Xiao, Xu, Jianye, Zhao, Rongrong, Xue, Hao, Li, Gang
Format: Article
Language:English
Subjects:
Adult
Angiogenesis
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Cancer Research
Cell adhesion & migration
Cell migration
Cell Movement
Epithelial-Mesenchymal Transition
Female
Gene Expression Regulation, Neoplastic
Gene set enrichment analysis
Genomes
Glioblastoma - genetics
Glioblastoma - metabolism
Glioblastoma - mortality
Glioblastoma - pathology
Glioma
Glioma - genetics
Glioma - metabolism
Glioma - mortality
Glioma - pathology
Guanine
Guanine Nucleotide Exchange Factors - genetics
Guanine Nucleotide Exchange Factors - metabolism
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Medical prognosis
Medicine
Medicine & Public Health
Mesenchyme
Middle Aged
Oncology
Original Article
Prognosis
Statistical analysis
Surgical Oncology
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Summary:Background PLEKHG5, a Rho-specific guanine-nucleotide exchange factor, is involved in tumor cell migration, invasion and angiogenic potential. In this study, the expression pattern, prognostic value and function of PLEKHG5 in gliomas were investigated. Methods Immunohistochemistry was used to determine the expression pattern of PLEKHG5 in 61 glioma patients after curative resection. Statistical analysis was performed to evaluate the diagnostic and prognostic significance of PLEKHG5. Gene ontology (GO) analysis, Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis and Gene set enrichment analysis (GSEA) were used to predict potential functions of PLEKHG5. Migration assay and western blot analysis determined PLEKHG5 function in glioma migration and invasion. Results Increased PLEKHG5 expression levels were associated with higher glioma grades ( P  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-019-01503-0