Recent progress in the applications of boron doped diamond electrodes in electroanalysis of organic compounds and biomolecules – A review

• Published in: Analytica chimica acta 2019-10, Vol.1077, p.30-66
• Main Authors: Baluchová, Simona, Daňhel, Aleš, Dejmková, Hana, Ostatná, Veronika, Fojta, Miroslav, Schwarzová-Pecková, Karolina
• Format: Article
• Language: English
• Subjects: Adsorptivity; Amino acids; Bases (nucleic acids); Biomolecules; Biosensors; Boron; Boron compounds; Boron doped diamond; Composite materials; Computational fluid dynamics; Computer applications; Deoxyribonucleic acid; Diamonds; DNA; Electrical measurement; Electroanalysis; Electrochemical analysis; Electrochemistry; Electrodes; Electrolytic analysis; Fabrication; Liquid flow; Microelectrodes; Non-enzymatic electroanalysis; Organic compounds; Peptides; Ribonucleic acid; RNA; Sensitivity enhancement; Surface chemistry; Surface treatment; Voltammetry
• ISSN: 0003-2670; 1873-4324
• DOI: 10.1016/j.aca.2019.05.041

This review summarizes progress in electroanalysis of organic compounds and biomacromolecules by means of bare BDD-based electrodes for the period of 2009–2018. New trends, which have emerged in the reported decade and which have improved their performance in batch voltammetric and amperometric methods and electrochemical detection in liquid flow techniques are commented. Importance of BDD surface termination, effect of boron doping level, and utilization of adsorption of analytes on BDD surfaces enabling development of adsorptive voltammetric techniques are addressed. Further, possibilities of simultaneous determination of analytes by means of voltammetric techniques utilizing computational approaches and multiple-pulse amperometric detection are discussed. Strategies leading to enhancement of sensitivity such as nanostructuring of the BDD surface, fabrication of BDD-based composite materials or new approaches in construction of microelectrodes and microelectrode arrays for biosensing represent another area of interest. Attention is paid to possibilities in detection of amino acids, peptides and proteins, nucleobases, nucleos(t)ides and DNA/RNA. [Display omitted] •Boron doped diamond as an electrode material for electroanalysis reviewed for the period of 2009–2018.•Progress in electroanalysis of organic compounds and biomacromolecules reported.•Only bare BDD surfaces including nanostructured architectures considered.•Effect of boron doping level, surface termination and proclivity to adsorption discussed.•Comprehensive table with > 340 references summarizing characteristics of voltammetric and amperometric methods included.