Selenium in Cardiac Surgery

Selenium (Se) is an essential trace element that plays a pivotal role in many of the body's regulatory and metabolic functions, especially during times of stress. After uptake, Se is incorporated into several Se‐dependent proteins, which have potent anti‐inflammatory and antioxidant capacities....

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Bibliographic Details
Published in:Nutrition in clinical practice 2019-08, Vol.34 (4), p.528-539
Main Authors: Wendt, Sebastian, Schomburg, Lutz, Manzanares, William, Stoppe, Christian
Format: Article
Language:English
Subjects:
antioxidant
cardiac surgery
Cardiac Surgical Procedures - adverse effects
Cardiovascular Diseases - etiology
Cardiovascular Diseases - surgery
critical care
Dietary Supplements
Humans
Nursing
Postoperative Complications - etiology
Postoperative Complications - therapy
selenium
Selenium - deficiency
Selenium - therapeutic use
selenium supplementation
selenium‐binding proteins
Trace Elements - deficiency
Trace Elements - therapeutic use
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Summary:Selenium (Se) is an essential trace element that plays a pivotal role in many of the body's regulatory and metabolic functions, especially during times of stress. After uptake, Se is incorporated into several Se‐dependent proteins, which have potent anti‐inflammatory and antioxidant capacities. Several observational clinical studies have demonstrated that Se deficiency can cause chronic cardiovascular diseases and aggravate organ dysfunction after cardiac surgery and that low levels of Se may be independently associated with the development of organ dysfunction after cardiac surgery. Based on these findings, several studies have investigated the effects of a perioperative Se supplementation strategy. Therefore, the present review describes in depth the pathophysiology and harmful stimuli during cardiac surgery, how Se may counteract these injuries, the different types of Se supplementation strategies that have been evaluated, and current evidence of its clinical significance.
ISSN:0884-5336
1941-2452
DOI:10.1002/ncp.10326