Thiazole in the targeted anticancer drug discovery

Cancer is known as one of the main causes of death in the world; and many compounds have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile heterocycle, found in the structure of many drugs in use as well as anticancer agents. This review provides an overview of r...

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Bibliographic Details
Published in:Future medicinal chemistry 2019-08, Vol.11 (16), p.1929-1952
Main Authors: Ayati, Adileh, Emami, Saeed, Moghimi, Setareh, Foroumadi, Alireza
Format: Article
Language:English
Subjects:
anticancer agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antitumor agents
Apoptosis
Apoptosis - drug effects
Binding sites
cancer
Cancer therapies
Cell cycle
Cell division
Chemotherapy
Colorectal cancer
Cyclin-Dependent Kinases - antagonists & inhibitors
Cyclin-Dependent Kinases - metabolism
Cytotoxicity
Drug Discovery
Drug resistance
ErbB Receptors - antagonists & inhibitors
ErbB Receptors - metabolism
Humans
Investigations
Kinases
Neoplasms - drug therapy
Neoplasms - pathology
Phosphatidylinositol 3-Kinases - chemistry
Phosphatidylinositol 3-Kinases - metabolism
Polymerization
signaling pathways
Structure-Activity Relationship
thiazole
Thiazoles - chemistry
Thiazoles - pharmacology
Thiazoles - therapeutic use
tumor cells
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Summary:Cancer is known as one of the main causes of death in the world; and many compounds have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile heterocycle, found in the structure of many drugs in use as well as anticancer agents. This review provides an overview of recent advances in thiazole-bearing compounds as anticancer agents with particular emphasis on their mechanism of action in cancerous cells. Chemical designs, structure–activity relationships and relevant preclinical properties have been comprehensively described.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2018-0416