Common Polymorphisms in Genes Related to Vitamin D Metabolism Affect the Response of Cognitive Abilities to Vitamin D Supplementation

It is possible that vitamin D acts as a neurosteroid and that vitamin D deficiency may have an adverse impact on brain function and cognitive function. There are a few reports that have demonstrated an association between polymorphisms of genes involved in vitamin D metabolism and neurodegenerative...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2019-09, Vol.69 (1), p.150-156
Main Authors: Bahrami, Afsane, Khayyatzadeh, Sayyed Saeid, Jaberi, Najmeh, Tayefi, Maryam, Mohammadi, Farzaneh, Ferns, Gordon A., Sadeghnia, Hamid Reza, Ghayour-Mobarhan, Majid
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Biomedical and Life Sciences
Biomedicine
Brain
Calciferol
Cell Biology
Cholestanetriol 26-Monooxygenase - genetics
Cognition
Cognitive ability
Cognitive tasks
Cytochrome P450 Family 2 - genetics
Female
Gene polymorphism
Genes
Genotypes
Genotyping
Humans
Metabolism
Neurochemistry
Neurodegenerative diseases
Neurological diseases
Neurology
Neurosciences
Polymorphism
Polymorphism, Single Nucleotide
Proteomics
Single-nucleotide polymorphism
Supplements
Vitamin D
Vitamin D - administration & dosage
Vitamin D - blood
Vitamin D - metabolism
Vitamin D3
Vitamin deficiency
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Summary:It is possible that vitamin D acts as a neurosteroid and that vitamin D deficiency may have an adverse impact on brain function and cognitive function. There are a few reports that have demonstrated an association between polymorphisms of genes involved in vitamin D metabolism and neurodegenerative disease. We aimed to evaluate the relationship between common, functional vitamin D–associated gene variants and cognitive abilities and to investigate the effect size of this polymorphism on cognitive capabilities associated with high-dose vitamin D supplementation. A total of 319 healthy adolescents received a high dose of vitamin D (50,000 IU)/week for 9 weeks. A questionnaire was used to assess cognitive abilities at baseline and after treatment. The genotypes of the CYP2R1-rs10766197 and GC-rs4588 variants were determined using TaqMan genotyping techniques. At baseline, total cognitive ability scores were higher in the AA group who were homozygous for the uncommon allele, compared with the other (AG and GG) genotypes of the CYP2R1 -rs10766197 polymorphism (104.9 ± 27.8 vs. 79.1 ± 38.8 vs. 73.1 ± 25.6; p  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-019-01344-6