Novel oral transforming growth factor‐β signaling inhibitor potently inhibits postsurgical adhesion band formation

Here, we have investigated the therapeutic potency of EW‐7197, a transforming growth factor‐β type I receptor kinase inhibitor, against postsurgical adhesion band formation. Our results showed that this pharmacological inhibitor prevented the frequency and the stability of adhesion bands in mice mod...

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Bibliographic Details
Published in:Journal of cellular physiology 2020-02, Vol.235 (2), p.1349-1357
Main Authors: Soleimani, Atena, Asgharzadeh, Fereshteh, Rahmani, Farzad, Avan, Amir, Mehraban, Saeedeh, Fakhraei, Maryam, Arjmand, Mohammad Hassan, Binabaj, Maryam Moradi, Parizadeh, Mohammad Reza, Ferns, Gordon A., Ryzhikov, Mikhail, Afshari, Amir Reza, Naghinezhad, Jalal, Sayyed‐Hosseinian, Sayyed Hadi, Khazaei, Majid, Hassanian, Seyed Mahdi
Format: Article
Language:English
Subjects:
Adhesion
Attenuation
Collagen
Cytokines
Edema
Enzyme inhibitors
EW‐7197
Fibrosis
Frequency stability
Growth factors
Inflammation
Inhibitors
Kinases
Oxidative stress
postsurgical adhesion band formation
Surgery
TGF‐β signaling
Transforming growth factor-b
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Summary:Here, we have investigated the therapeutic potency of EW‐7197, a transforming growth factor‐β type I receptor kinase inhibitor, against postsurgical adhesion band formation. Our results showed that this pharmacological inhibitor prevented the frequency and the stability of adhesion bands in mice model. We have also shown that downregulation of proinflammatory cytokines, reduce submucosal edema, attenuation of proinflammatory cell infiltration, inhibition of oxidative stress, decrease in excessive collagen deposition, and suppression of profibrotic genes at the site of surgery are some of the mechanisms by which EW‐7197 elicits its protective responses against adhesion band formation. These results clearly suggest that EW‐7197 has novel therapeutic properties against postsurgical adhesion band formation with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in postsurgery patients. Here, we have investigated the therapeutic potency of EW‐7197, a transforming growth factor‐β type I receptor kinase inhibitor, against postsurgical adhesion band formation. Our results showed that this pharmacological inhibitor prevented the frequency and the stability of adhesion bands in mice model.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.29053