Oxidative Mannich Reactions of Tertiary Amines Using a Cu(II) 2‑Quinoxalinol Salen Catalyst

Oxidative Mannich reactions can be catalyzed using a Cu­(II) 2-quinoxalinol salen catalyst and with tert-butyl hydroperoxide (TBHP). Under mild conditions, a range of both cyclic and open chain tertiary amines was tested as substrates, resulting in yields up to 98%.

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Bibliographic Details
Published in:Journal of organic chemistry 2019-08, Vol.84 (15), p.9806-9810
Main Authors: Black, Clayton C, Gorden, Anne E.V
Format: Article
Language:English
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Summary:Oxidative Mannich reactions can be catalyzed using a Cu­(II) 2-quinoxalinol salen catalyst and with tert-butyl hydroperoxide (TBHP). Under mild conditions, a range of both cyclic and open chain tertiary amines was tested as substrates, resulting in yields up to 98%.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b01409