Understanding the Signaling Pathways Related to the Mechanism and Treatment of Diabetic Peripheral Neuropathy

Worldwide, the most prevalent metabolic disorder is diabetes mellitus (DM), an important condition that has been widely studied. Diabetic peripheral neuropathy (DPN), a complication that can occur with DM, is associated with pain and can result in foot ulcers and even amputation. DPN treatments are...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2019-09, Vol.160 (9), p.2119-2127
Main Authors: Tang, He-Yong, Jiang, Ai-Juan, Ma, Jun-Long, Wang, Fan-Jing, Shen, Guo-Ming
Format: Article
Language:English
Subjects:
Amputation
Analysis
Animals
Care and treatment
Cellular signal transduction
Development and progression
Diabetes
Diabetes mellitus
Diabetic nephropathies
Diabetic Neuropathies - drug therapy
Diabetic Neuropathies - physiopathology
Diagnosis
Dyslipidemias - complications
Endocrinology
Glycosylation
Humans
Metabolic disorders
Nerve Growth Factors - physiology
Oxidative Stress
Pain
Peripheral Nervous System Diseases - drug therapy
Peripheral Nervous System Diseases - physiopathology
Peripheral neuropathy
Protein Kinase C - physiology
Signal transduction
Signal Transduction - physiology
Signaling
Ulcers
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Summary:Worldwide, the most prevalent metabolic disorder is diabetes mellitus (DM), an important condition that has been widely studied. Diabetic peripheral neuropathy (DPN), a complication that can occur with DM, is associated with pain and can result in foot ulcers and even amputation. DPN treatments are limited and mainly focus on pain management. There is a clear need to develop treatments for DPN at all stages. To make this progress, it is necessary to understand the molecular signaling pathways related to DPN. For this review, we aimed to concentrate on the main signaling cascades that contribute to DPN. In addition, we provide information with regard to treatments that are being explored.
ISSN:1945-7170
0013-7227
1945-7170
DOI:10.1210/en.2019-00311