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Cost-Effectiveness of Proton Versus Photon Therapy in Pediatric Medulloblastoma Treatment: A Patient Volume–Based Analysis

Proton radiation therapy offers advantages over photon therapy, assisting with severe side effect avoidance. Pediatric patients with medulloblastoma have demonstrated benefit from this technology in recently published cohort studies. To compare the costs and benefits between proton and photon therap...

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Published in:Value in health regional issues 2019-12, Vol.20, p.122-128
Main Authors: Fernandes, Ricardo Ribeiro Alves, Vianna, Cid Manso de Mello, Guerra, Renata Leborato, Cancela, Marianna de Camargo, Almeida, Liz Maria de, Pereira, Adail José da Conceição, Viégas, Célia Maria Pais, Ferman, Sima Esther, Corrêa, Flávia de
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Language:English
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Summary:Proton radiation therapy offers advantages over photon therapy, assisting with severe side effect avoidance. Pediatric patients with medulloblastoma have demonstrated benefit from this technology in recently published cohort studies. To compare the costs and benefits between proton and photon therapy in treating pediatric medulloblastoma. The model was built with a lifetime horizon from the Brazilian health system perspective using a 3% discount rate. A microsimulation model was developed after a literature search, comparing scenarios of equipment life span and number of patients treated per year (50, 100, and 150 patients with 10, 25, and 20 years of equipment life span). The baseline parameters were 50 patients treated annually and 20 years of equipment life span. The quality-adjusted life-year gain was 2.71, and the average incremental cost-effectiveness ratio was $34 590.54 per quality-adjusted life-year. For the willingness-to-pay threshold of 1 gross domestic product per capita, it was observed that the incorporation of the technology would be cost-effective if more than 150 patients were treated per year. The weight of the equipment life span and other variables was limited when it varied in the sensitivity analysis, without significant changes to the model results. Proton therapy is not cost-effective for pediatric medulloblastoma treatment from the Brazilian health system perspective. The investment is not worth when considering the number of potential patients and the country dimensions. •Several articles were published assessing the cost-effectiveness of proton therapy for pediatric medulloblastoma. These studies did not assess the demand for the technology in the sensitivity analysis, which we identified as an important limitation.•In this article, we show that considering the demand in the analysis has great impact and can change the results of the decision recommendation.•Pediatric medulloblastoma is a relatively rare disease, and the number of patients treated can be insufficient to turn the investment in proton therapy to be cost-effective in certain willingness-to-pay thresholds. Even in Brazil, the demand might not be sufficient to justify the investment.
ISSN:2212-1099
2212-1102
DOI:10.1016/j.vhri.2019.03.006