Chlorhexidine sensitivity in staphylococci isolated from patients with central line-associated bloodstream infection

Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in inte...

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Bibliographic Details
Published in:The Journal of hospital infection 2019-11, Vol.103 (3), p.276-279
Main Authors: Jun, K.I., Choi, Y., Kwon, K., Shin, M.J., Park, J.S., Song, K-H., Kim, E.S., Park, K-H., Jung, S-I., Cheon, S.H., Kim, Y-S., Yoon, N-R., Kim, D.M., Choe, P.G., Kim, N.J., Kim, H.B.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bacteremia - microbiology
Catheter-Related Infections - microbiology
Catheterization, Central Venous - adverse effects
Central line-associated bloodstream infection
Chlorhexidine - pharmacology
Chlorhexidine resistance
Disinfectants - pharmacology
Female
Humans
Intensive Care Units
Korea
Male
Microbial Sensitivity Tests
Middle Aged
Minimum bactericidal concentration
Minimum inhibitory concentration
Staphylococcal Infections - microbiology
Staphylococcus - drug effects
Staphylococcus - isolation & purification
Staphylococcus aureus
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Summary:Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2% chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2019.07.009