Spectro-electrochemistry of ciprofloxacin and probing its interaction with bovine serum albumin

In the present investigation the electrochemical behaviour of the drug, Ciprofloxacin (Cf) and its interaction with the Bovine Serum Albumin (BSA) is reported. UV-Visible Spectroscopy (UV-Vis) and Spectro-electrochemical measurements were carried out to quantify the charge transfer process in Cf. An...

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Bibliographic Details
Published in:Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2019-12, Vol.130, p.107330-107330, Article 107330
Main Authors: Ipte, Priyanka R, Sahoo, Srikant, Satpati, A K
Format: Article
Language:English
Subjects:
Binding
Bovine serum albumin
Charge transfer
Ciprofloxacin
Diffusivity
Electrochemical analysis
Electrochemical oxidation
Electrochemistry
Electron transfer
Investigations
Microelectrodes
Oxidation
Oxidation process
Serum albumin
Spectroscopy
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Summary:In the present investigation the electrochemical behaviour of the drug, Ciprofloxacin (Cf) and its interaction with the Bovine Serum Albumin (BSA) is reported. UV-Visible Spectroscopy (UV-Vis) and Spectro-electrochemical measurements were carried out to quantify the charge transfer process in Cf. Analysis of the results obtained from cyclic voltammetry (CV) measurements indicated the electrochemical oxidation of Cf followed mixed adsorption and diffusion control process. The spectro-electrochemical investigations were carried out and the modification of the spectral peaks were monitored to obtain the mechanism of the electrochemical oxidation process of Cf. Interaction of Cf with Bovine Serum Albumin (BSA) were investigated using electrochemical, spectroscopic and spectro-electrochemical experiments. Important electro-kinetic parameters like; the electron transfer property, binding constant and diffusivity of the Cf/BSA complex were investigated. Electrochemistry with an ultra-microelectrode was utilised to investigate the diffusivity of the drug and its complex with BSA, which supports the strong binding of Cf with BSA.
ISSN:1567-5394
1878-562X
DOI:10.1016/j.bioelechem.2019.107330