Antiviral agents against African swine fever virus

•African swine fever virus (ASFV) has moved beyond Africa because of no effective control measures.•Vaccines or antiviral drugs against ASFV are currently not available.•Several compounds that target a viral or a host factor inhibit the in vitro replication of ASFV.•For anti-ASFV compounds, in vivo...

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Published in:Virus research 2019-09, Vol.270, p.197669-197669, Article 197669
Main Authors: Arabyan, Erik, Kotsynyan, Armen, Hakobyan, Astghik, Zakaryan, Hovakim
Format: Article
Language:English
Subjects:
African swine fever virus
Antiviral
Flavonoid
Nucleoside
Pig
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creator Arabyan, Erik
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description •African swine fever virus (ASFV) has moved beyond Africa because of no effective control measures.•Vaccines or antiviral drugs against ASFV are currently not available.•Several compounds that target a viral or a host factor inhibit the in vitro replication of ASFV.•For anti-ASFV compounds, in vivo efficacy is not evaluated yet. African swine fever virus (ASFV) is a significant transboundary virus that continues to spread outside Africa in Europe and most recently to China, Vietnam and Cambodia. Pigs infected with highly virulent ASFV develop a hemorrhagic fever like illness with high lethality reaching up to 100%. There are no vaccines or antiviral drugs available for the prevention or treatment of ASFV infections. We here review molecules that have been reported to inhibit ASFV replication, either as direct-acting antivirals or host-targeting drugs as well as those that act via a yet unknown mechanism. Prospects for future antiviral research against ASFV are also discussed.
doi_str_mv 10.1016/j.virusres.2019.197669
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subjects African swine fever virus
Antiviral
Flavonoid
Nucleoside
Pig
title Antiviral agents against African swine fever virus
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