Gadoxetate disodium-related event during image acquisition: a prospective multi-institutional study for better MR practice

Purpose To acknowledge the facts of gadoxetate disodium-related events in Japan and to achieve better MR practice by analyzing large cohort data with various MR parameters. Materials and methods This prospective multi-institutional study included 1993 patients (1201 men, mean age 66.4 ± 12.8 years),...

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Bibliographic Details
Published in:European radiology 2020-01, Vol.30 (1), p.281-290
Main Authors: Kromrey, Marie-Luise, Hori, Masatoshi, Goshima, Satoshi, Kozaka, Kazuto, Hyodo, Tomoko, Nakamura, Yuko, Nishie, Akihiro, Tamada, Tsutomu, Shimizu, Tatsuya, Kanki, Akihiko, Motosugi, Utaroh
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Breath Holding
Contrast agents
Contrast Media
Contrast Media - administration & dosage
Diagnostic Radiology
Dyspnea
Failure
Female
Gadolinium
Gadolinium DTPA - administration & dosage
Humans
Image acquisition
Image enhancement
Image quality
Imaging
Internal Medicine
Interventional Radiology
Japan
Liver Neoplasms - diagnostic imaging
Logistic Models
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Parameters
Prospective Studies
Radiology
Regression analysis
Regression models
Respiration
Risk Factors
Side effects
Ultrasound
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Summary:Purpose To acknowledge the facts of gadoxetate disodium-related events in Japan and to achieve better MR practice by analyzing large cohort data with various MR parameters. Materials and methods This prospective multi-institutional study included 1993 patients (1201 men, mean age 66.4 ± 12.8 years), who received dynamic MRI with gadoxetate disodium (gadoxetate group, n  = 1646) or extracellular gadolinium-based contrast agents (other-GBCAs group, n  = 347) between January and November 2016. Recorded data covered adverse reactions including dyspnea, breath-hold failure during acquisition, respiratory artifacts rated with a four-point scale, and MR parameters. We compared data between the two groups in whole cohort and age-, gender-, and institution-matched subcohort using χ 2 test ( n  = 640). Logistic regression model was used to reveal independent associates of substantial artifacts in arterial phase imaging. Results Transient dyspnea rarely occurred in gadoxetate or other-GBCAs group (both
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-019-06358-7