Association between dietary glycemic index and liver enzymes level among apparently healthy adults

• Published in: Diabetes & metabolic syndrome clinical research & reviews 2019-03, Vol.13 (2), p.1597-1602
• Main Authors: Moshtaq, Mohammad Ali, Rahimi, Mohammad Hossein, Mollahosseini, Mehdi, Khorrami-Nezhad, Leila, Maghbooli, Zhila, Mirzaei, Khadijeh, Pooyan, Sara, Setayesh, Leila
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; ALT; AST; Biomarkers - analysis; Blood Glucose - analysis; Body Mass Index; Cross-Sectional Studies; Diet; Dietary glycemic index; Energy Intake; Female; Follow-Up Studies; Glycemic Index; Healthy Volunteers; Humans; Liver - enzymology; Male; Middle Aged; People without a specific disease; Prognosis; Surveys and Questionnaires; Young Adult
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2019.03.013

The previous studies have revealed that there is a link between dietary glycemic index and lipid profile in overweight and obesity. The aim of study was to investigate whether the glycemic index is associated with liver enzymes. Anthropometric and biochemical parameters were measured in 265 participants. Dietary glycemic index (GI) was assessed by using a validated food-frequency questionnaire. With adjusting confounder variable, Binary logistic regression was also used to predict the relationship between liver enzymes and quartile of intake. There was a significant difference between low and high GI diet for BMR (P = 0.01), FFM (P = 0.03), TG (P = 0.02), HDL (P = 0.002). The association between HDL and glycemic index remained significant after adjustment of sex and age (P = 0.03). Using the regression model following adjustment revealed that for each 1% increase in the degree of the GI, there was 11% elevation in liver enzyme abnormalities. In both groups of men and women, enzyme abnormalities positively correlated with GI, while only men showed remarkable correlation in all models (crude model: β = 0.07, OR = 1.07, CI = 0.98to 1.16). Additionally, an increase in the degree of GI caused an elevation in enzyme abnormalities by 7%. With adjusting sex, age, BMI, and Physical activity, a significance correlation was found between GI and Enzyme abnormalities (p-value = 0.03, OR = 1.115). Our study indicated that high glycemic index diet led to the elevated levels of the liver enzymes, while being significant only in men.