Anatomical meniscus construct with zone specific biochemical composition and structural organization

A PCL/hydrogel construct that would mimic the structural organization, biochemistry and anatomy of meniscus was engineered. The compressive (380 ± 40 kPa) and tensile modulus (18.2 ± 0.9 MPa) of the PCL scaffolds were increased significantly when constructs were printed with a shifted design and cir...

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Bibliographic Details
Published in:Biomaterials 2019-10, Vol.218, p.119361-119361, Article 119361
Main Authors: Bahcecioglu, G., Bilgen, B., Hasirci, N., Hasirci, V.
Format: Article
Language:English
Subjects:
3D printing
Circumferential fiber orientation
Human fibrochondrocytes
PCL/Dual hydrogel
Zone-specific biochemical composition
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Summary:A PCL/hydrogel construct that would mimic the structural organization, biochemistry and anatomy of meniscus was engineered. The compressive (380 ± 40 kPa) and tensile modulus (18.2 ± 0.9 MPa) of the PCL scaffolds were increased significantly when constructs were printed with a shifted design and circumferential strands mimicking the collagen organization in native tissue (p 
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2019.119361