The subdivision behavior of polymeric tablets

[Display omitted] The subdivision behavior of polymeric tablets produced with the well-known polymers Soluplus® (SOL), polyvinyl pyrrolidone co-vinyl acetate (PVPVA) and hydroxypropyl methylcellulose (HPMC) was evaluated in this study. The polymeric tablets were submitted to different post-treatment...

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Bibliographic Details
Published in:International journal of pharmaceutics 2019-09, Vol.568, p.118554-118554, Article 118554
Main Authors: Cunha-Filho, Marcilio, Teixeira, Maíra T., Santos-Rosales, Víctor, Sa-Barreto, Livia L., Marreto, Ricardo N., Martin-Pastor, Manuel, García-González, Carlos A., Landin, Mariana
Format: Article
Language:English
Subjects:
Carbon Dioxide - chemistry
Friability
Hot Temperature
Hot-melt extrusion
Hypromellose Derivatives - chemistry
Mass loss
Mass variation
Polyethylene Glycols - chemistry
Polymeric tablets
Polyvinyls - chemistry
Povidone - analogs & derivatives
Povidone - chemistry
Tablet subdivision
Tablets
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Summary:[Display omitted] The subdivision behavior of polymeric tablets produced with the well-known polymers Soluplus® (SOL), polyvinyl pyrrolidone co-vinyl acetate (PVPVA) and hydroxypropyl methylcellulose (HPMC) was evaluated in this study. The polymeric tablets were submitted to different post-treatments (aging, thermal and exposure to compressed gaseous carbon dioxide) and its mechanical, spectroscopic and microstructure properties were assessed. SOL tablets showed the best results for tablet subdivision, particularly, the mean mass variation (3.9%) was significantly lower than the other two polymeric tablets (7.2% and 9.1% for PVPVA and HPMC, respectively), and showed better results than common tablets produced from powder matrices (7–14%). SOL tablets were also more sensitive to the different post-treatments applied, which reduced the mass loss and friability from 1.5% and 0.8%, respectively, to values close to zero and without altering their porosity. The thermal treatment of PVPVA tablets, in turn, also led to similar subdivision results, with mass loss of 0.3% and friability of 0.02%. In contrast, the granules of HPMC presented compaction difficulties making its tablets unsuitable for the subdivision process, even after additional post-treatment. Polymeric matrices with uniform internal structure and appropriate mechanical strength are the key to a better adaptation for the tablet subdivision.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2019.118554