Usefulness of the Transcatheter Aortic Valve Replacement Risk Score to Determine Mid-Term Outcomes

• Published in: Circulation Journal 2019/07/25, Vol.83(8), pp.1755-1761
• Main Authors: Saji, Mike, Tobaru, Tetsuya, Higuchi, Ryosuke, Mahara, Keitaro, Takamisawa, Itaru, Iguchi, Nobuo, Doi, Shinichiro, Okazaki, Shinya, Tamura, Harutoshi, Takanashi, Shuichiro, Takayama, Morimasa, Isobe, Mitsuaki
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; All-cause death; Aortic Valve - diagnostic imaging; Aortic Valve - physiopathology; Aortic Valve - surgery; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - mortality; Aortic Valve Stenosis - physiopathology; Aortic Valve Stenosis - surgery; Biomarkers - blood; Body Mass Index; Cause of Death; Decision Support Techniques; Female; Humans; Japan; Male; Mid-term outcomes; Postoperative Complications - mortality; Predictive model; Predictive Value of Tests; Recovery of Function; Retrospective Studies; Risk Assessment; Risk Factors; Serum Albumin, Human - metabolism; Severity of Illness Index; TAVR, TAVI, STS score; Time Factors; Transcatheter Aortic Valve Replacement - adverse effects; Transcatheter Aortic Valve Replacement - mortality; Treatment Outcome
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-18-1394

Background:The purpose of this study was to investigate if the transcatheter aortic valve replacement (TAVR) risk score can independently predict outcomes following TAVR, and to evaluate its predictive performance.Methods and Results:This retrospective multicenter study comprised 682 patients with severe aortic stenosis who underwent TAVR. The primary endpoint was all-cause death following TAVR. The clinical model was established using variables identified as independent predictors in the multivariate analysis. Incremental values were assessed after adding atrial fibrillation, body mass index (BMI), and serum albumin to the TAVR risk score in receiver-operating characteristic analysis. The median TAVR risk score was 2.1% with a mean follow-up of 505 days. On Kaplan-Meier analysis, a TAVR risk score >4% had lowest survival rate, whereas TAVR risk score ≤2% had the highest survival rate at 3 years (log-rank P