Near-infrared triggered antibacterial nanocomposite membrane containing upconversion nanoparticles

• Published in: Materials Science & Engineering C 2019-10, Vol.103, p.109797-109797, Article 109797
• Main Authors: Sun, Jing, Zhang, Ping, Fan, Yong, Zhao, Jie, Niu, Shichao, Song, Lingjie, Ma, Li, Ren, Luquan, Ming, Weihua
• Format: Article
• Language: English
• Subjects: Animals; Antibacterial; Antibacterial materials; Antibiotic resistance; Antibiotics; Bactericidal activity; Biocides; Cell Line; Cell Survival - drug effects; Cytotoxicity; Disk Diffusion Antimicrobial Tests; E coli; Electrospinning; Escherichia coli - radiation effects; I.R. radiation; Infrared Rays; Irradiation; Mammalian cells; Materials science; Membranes, Artificial; Methylene Blue - chemistry; Mice; Nanocomposite membrane; Nanocomposites; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - toxicity; Near infrared radiation; Photosensitizing Agents - chemical synthesis; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Polyvinyls - chemistry; Quantum Theory; Reactive oxygen species; Reactive Oxygen Species - chemistry; Reactive Oxygen Species - metabolism; Staphylococcus aureus - drug effects; Toxicity; Upconversion; Upconversion nanoparticle; Wound healing
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2019.109797

Many conventional bactericidal materials exhibit antibacterial activities by releasing biocides, which potentially trigger antibiotic resistance and cause environmental concerns. In the present work, we reported the development of antibacterial nanocomposite membrane containing upconversion nanoparticles (UCNPs) by electrospinning. The nanocomposite membrane itself was not bactericidal but exhibits strongly antimicrobial performance on demand as activated by near-infrared (NIR) light. Upon just 5 min of NIR irradiation, the UCNPs in the nanocomposite membrane could trigger the release of reactive oxygen species (ROS) from photosensitizers, which could kill both Gram-positive Staphylococcus aureus (94.5%) and Gram-negative Escherichia coli (93.2%) rapidly. Moreover, the bactericidal activity could be effectively maintained for at least four cycles. In addition, the nanocomposite membrane showed no adverse effects on the mammalian cells, as verified by a cytotoxicity assay. This work provided a new strategy in designing novel antibacterial materials that might be potentially applied in infection-resistant and wound healing. Upon NIR irradiation, the UCNPs in the nanocomposite membrane trigger the release of reactive oxygen species (ROS) from photosensitizers that rapidly killed both Gram-positive and Gram-negative bacteria. [Display omitted] •The membrane itself is not bactericidal but becomes strongly antimicrobial on demand.•Upon NIR irradiation, the membrane demonstrates rapid bactericidal performances.•The bactericidal activity can be effectively maintained for multi-cycles.