Wrist circumference is a biomarker of adipose tissue dysfunction and cardiovascular risk in children with obesity

• Published in: Journal of endocrinological investigation 2020, Vol.43 (1), p.101-107
• Main Authors: Luordi, C., Maddaloni, E., Bizzarri, C., Pedicelli, S., Zampetti, S., D’Onofrio, L., Moretti, C., Cappa, M., Buzzetti, R.
• Format: Article
• Language: English
• Subjects: Adiponectin; Adipose tissue; Blood pressure; Body mass index; Body weight; Cardiovascular diseases; Children; Clothing industry; Diabetes mellitus; Dual energy X-ray absorptiometry; Endocrinology; Insulin; Internal Medicine; Leptin; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic syndrome; Obesity; Original Article; Overweight; Placebo effect; Triglycerides; Wrist
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-019-01086-7

Purpose To evaluate the relationship between wrist circumference, markers of adipose dysfunction, and cardiovascular risk in youths with obesity. Methods In this cross-sectional study, we measured body mass composition by dual-energy X-ray absorptiometry, wrist circumference, waist-to-height ratio, fasting blood insulin, glucose, lipid profile, adiponectin, and leptin in 280 children with overweight/obesity and without diabetes (age: 7–18 years). Cardiovascular risk was estimated by “metabolic syndrome score” (MetS score). Results Study participants had median [25th–75th percentile] wrist circumference of 17.5 [16.7–18.5] cm and waist-to-height ratio of 0.62 [0.59–0.67]. Lower adiponectin–leptin ratio was found among subjects in the upper 50th percentiles of wrist circumference [0.17 (0.09–0.36) vs. 0.38 (0.16–0.79); p