Relationships between Body Composition and Plasma Levels of Pancreatic, Gut, and Adipose Tissue Hormones in db/db Mice, a Model of Type 2 Diabetes Mellitus

We studied the relationships between body composition parameters and plasma levels of pancreatic, gut, and adipose tissue hormones regulating energy balance and glucose metabolism in diabetic db/db mice (BKS.Cg-Dock7 m+/+ Lepr db /J). The body composition parameters in mice aged 8, 12, and 16 weeks...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-07, Vol.167 (3), p.325-328
Main Authors: Korbut, A. I., Klimontov, V. V., Orlov, N. B., Khotskina, A. S., Zav’yalov, E. L.
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Adipose tissues
Animals
Biomedical and Life Sciences
Biomedicine
Body composition
Body Composition - physiology
Body fat
Body mass
Body weight
Cell Biology
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Energy balance
Energy metabolism
Gastrointestinal Hormones - blood
Ghrelin
Ghrelin - blood
Glucagon
Glucagon - blood
Glucagon-like peptide 1
Glucagon-Like Peptide 1 - blood
Glucose
Glucose - metabolism
Insulin
Insulin - blood
Internal Medicine
Laboratory Medicine
Lean body mass
Leptin
Leptin - blood
Linagliptin
Magnetic resonance imaging
Male
Mice
Mice, Inbred NOD
Pancreas
Pancreatic Hormones - blood
Pathology
Peptides
Physiological aspects
Plasma levels
Plasminogen Activators - blood
Resistin - blood
Rodents
Type 2 diabetes
Water content
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Summary:We studied the relationships between body composition parameters and plasma levels of pancreatic, gut, and adipose tissue hormones regulating energy balance and glucose metabolism in diabetic db/db mice (BKS.Cg-Dock7 m+/+ Lepr db /J). The body composition parameters in mice aged 8, 12, and 16 weeks were assessed by magnetic resonance imaging. The concentrations of insulin, glucagon, ghrelin, glucagon-like peptide-1, glucose-dependent immunotropic peptide, leptin, resistin, and plasminogen activator-1 were measured by multiplex analysis at the age of 8 and 16 weeks. In comparison with non-diabetic control ( db/+ ), db/db mice demonstrated high fat mass and reduced lean body mass and water content. In 8- and 16-week-old db/db mice, the levels of leptin ( p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04519-8