Magnetic Resonance Imaging in Assessment of Cardiac Remodeling in Rats with Experimental Arterial Hypertension

Magnetic resonance imaging was employed to examine the morphofunctional status of myocardium in Wistar rats with multifactor cardiovasorenal model of arterial hypertension. In 3 months after the onset of experiment, the rats demonstrated a pronounced hypertrophy in left ventricular myocardium mostly...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-07, Vol.167 (3), p.320-324
Main Authors: Agafonova, I. G., Kotel’nikov, V. N., Geltser, B. I.
Format: Article
Language:English
Subjects:
Animal experimentation
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Functional morphology
Heart
Heart - physiopathology
Heart enlargement
Hypertension
Hypertension - pathology
Hypertrophy
Internal Medicine
Laboratory Medicine
Magnetic Resonance Imaging
Male
Myocardium
Myocardium - pathology
NMR
Nuclear magnetic resonance
Pathology
Rats
Rats, Wistar
Septum
Ventricle
Ventricular Function, Left - physiology
Ventricular Remodeling - physiology
Ventricular Septum - physiology
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Summary:Magnetic resonance imaging was employed to examine the morphofunctional status of myocardium in Wistar rats with multifactor cardiovasorenal model of arterial hypertension. In 3 months after the onset of experiment, the rats demonstrated a pronounced hypertrophy in left ventricular myocardium mostly due to thickening of the posterior and lateral walls against the background of relatively stable thickness of ventricular septum. The left ventricular endsystolic volume markedly increased in parallel with moderate increase of the end-diastolic volume. The standard calculated indices were used for precise assessment of the type of remodeling of individual myocardial structures. The study showed that multifactor arterial hypertension model was characterized by domination of hypertrophic mode of the left ventricular remodeling, whereas the concentric variant was observed more rarely by 2.5 times. The greatest alterations were observed in the posterior and lateral walls of the left ventricle, which could result from the hemodynamic effects of hypervolemic arterial hypertension.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04518-9