Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field

This work presents direct evidence of disordering of liposomal membranes by magnetic nanoparticles during their exposures to non-heating alternating Extremely Low Frequency Magnetic Field (ELF MF). Changes in the lipid membrane structure were demonstrated by the Attenuated total reflection Fourier T...

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Bibliographic Details
Published in:Nanomedicine 2019-10, Vol.21, p.102065-102065, Article 102065
Main Authors: Le-Deygen, Irina M., Vlasova, Kseniya Yu, Kutsenok, Ekaterina O., Usvaliev, Azizbek D., Efremova, Maria V., Zhigachev, Alexander O., Rudakovskaya, Polina G., Golovin, Dmitry Yu, Gribanovsky, Sergey L., Kudryashova, Elena V., Majouga, Alexander G., Golovin, Yury I., Kabanov, Alexander V., Klyachko, Natalia L.
Format: Article
Language:English
Subjects:
ATR-FTIR spectroscopy
Extremely low frequency magnetic field (ELF MF)
Liposome
Magnetic nanoparticles
Remote control
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Summary:This work presents direct evidence of disordering of liposomal membranes by magnetic nanoparticles during their exposures to non-heating alternating Extremely Low Frequency Magnetic Field (ELF MF). Changes in the lipid membrane structure were demonstrated by the Attenuated total reflection Fourier Transform Infrared and fluorescence spectroscopy. Specifically, about 50% of hydrophobic chains became highly mobile under the action of ELF MF. Magnetic field-induced increase in the membrane fluidity was accompanied by an increase in membrane permeability and release of solutes entrapped in liposomes. The effect of ELF MF on the membrane fluidity was greater in case of 70 × 12 nm magnetite nanorods adsorbed on the liposomes surface compared to liposomes with ~7 nm spherical MNPs embedded within lipid membranes. A physical model of this process explaining experimental data is suggested. The obtained results open new horizons for the development of systems for triggered drug release without dangerous heating and overheating of tissues. Local disordering of liposomal membrane accompanied by the release of the liposome cargo produced by the oscillation of membrane-bound magnetic nanorods under alternating extremely low frequency magnetic field (MF) revealed by molecular spectroscopy and theoretical calculations. [Display omitted]
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2019.102065