Preclinical evaluation of porcine colon resection using hollow core negative curvature fibre delivered ultrafast laser pulses

Ultrashort pulse lasers offer great promise for tissue resection with exceptional precision and minimal thermal damage. Surgery in the bowel requires high precision and minimal necrotic tissue to avoid severe complications such as perforation. The deployment of ultrashort lasers in minimally invasiv...

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Bibliographic Details
Published in:Journal of biophotonics 2019-11, Vol.12 (11), p.e201900055-n/a
Main Authors: Mohanan, Syam M. P. C., Beck, Rainer J., West, Nicholas P., Shires, Michael, Perry, Sarah L., Jayne, David G., Hand, Duncan P., Shephard, Jonathan D.
Format: Article
Language:English
Subjects:
Ablation Techniques - instrumentation
Animals
Colon
Colon - cytology
Colon - surgery
Curvature
Damage
Fibers
Galvanometers
Intestine
Laser ablation
Lasers
negative curvature fibre
Optical fibers
Perforation
plasma‐mediated ablation
porcine colon
Surgery
Swine
thermal necrosis
ultrafast laser surgery
Ultrafast lasers
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Summary:Ultrashort pulse lasers offer great promise for tissue resection with exceptional precision and minimal thermal damage. Surgery in the bowel requires high precision and minimal necrotic tissue to avoid severe complications such as perforation. The deployment of ultrashort lasers in minimally invasive or endoscopic procedures has been hindered by the lack of suitable optical fibres for high peak powers. However, recent developments of hollow core microstructured fibres provide potential for delivery of such pulses throughout the body. In this study, analysis of laser ablation via a scanning galvanometer on a porcine colon tissue model is presented. A thermally damaged region (
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201900055