Combined Effect of Bone Morphogenetic Protein-2 and Erythropoietin on Regeneration of Cranial Bone Defects in Mice

Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-07, Vol.167 (3), p.408-412
Main Authors: Gromov, A. V., Bartov, M. S., Orlova, P. A., Manskikh, V. N., Krivozubov, M. S., Grunina, T. M., Manukhina, M. S., Strukova, N. V., Nikitin, K. E., Lunin, V. G., Karyagina, A. S., Gintsburg, A. L.
Format: Article
Language:English
Subjects:
Analysis
Animals
Biomedical and Life Sciences
Biomedicine
Bone growth
Bone morphogenetic protein 2
Bone Morphogenetic Protein 2 - pharmacology
Bone morphogenetic proteins
Bone Regeneration - drug effects
Bone Regeneration - physiology
Cell Biology
Disease Models, Animal
Erythropoietin
Erythropoietin - pharmacology
Erythropoietin, Recombinant
Glycoproteins
Internal Medicine
Laboratory Medicine
Male
Mice
Mice, Inbred ICR
Pathology
Regeneration
Skull
Skull - abnormalities
Skull - growth & development
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Summary:Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved quantitative and qualitative characteristics of the bone tissue in the site of implantation when used in combination with BMP-2 in both concentrations.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04538-5