Frailty as a prognostic indicator in the radical cystectomy population: a review

Radical cystectomy and urinary diversion are the current gold standard of management for patients with muscle-invasive bladder cancer. While it is a common urologic procedure, it is associated with significant patient morbidity and mortality. Complications associated with the operation are often fre...

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Bibliographic Details
Published in:International urology and nephrology 2019-08, Vol.51 (8), p.1281-1290
Main Authors: Parikh, Niki, Sharma, Pranav
Format: Article
Language:English
Subjects:
Aged
Bladder cancer
Cystectomy - methods
Frailty
Frailty - complications
Frailty - diagnosis
Geriatric Assessment
Humans
Invasiveness
Medicine
Medicine & Public Health
Morbidity
Neoplasm Invasiveness
Nephrology
Prognosis
Quality of life
Risk Factors
Urinary Bladder Neoplasms - complications
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
Urinary Diversion
Urology
Urology - Review
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Summary:Radical cystectomy and urinary diversion are the current gold standard of management for patients with muscle-invasive bladder cancer. While it is a common urologic procedure, it is associated with significant patient morbidity and mortality. Complications associated with the operation are often frequent, although minor, and significantly impact functional outcomes as well as patient quality of life. Frailty is emerging as a new preoperative prognostic indicator to help determine which patients are at greatest risk of poor outcomes and postoperative complications after treatment. In this review, we summarize the current known literature analyzing frailty as a significant prognostic risk factor of short-term and long-term outcomes after radical cystectomy and urinary diversion in the treatment of muscle-invasive bladder cancer.
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-019-02189-z