The association between cumulative C-reactive protein and brachial–ankle pulse wave velocity

• Published in: Aging clinical and experimental research 2020-05, Vol.32 (5), p.789-796
• Main Authors: Sun, Lixia, Ning, Chunhong, Liu, Jiqiang, Yao, Tao, Zhang, Li, Zhao, Lei, Wei, Xiaoxuan, Zhang, Xiaoling, Gao, Yang, Zhang, Ruiying, Wu, Shouling
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aging; Ankle; Ankle Brachial Index; Ankle Joint; Arteriosclerosis; C-Reactive Protein - analysis; Cohort Studies; Cross-Sectional Studies; Female; Geriatrics/Gerontology; Humans; Inflammation; Laboratories; Male; Medicine; Medicine & Public Health; Middle Aged; Odds Ratio; Original Article; Proteins; Pulse Wave Analysis; Regression analysis; Risk Factors; Standard deviation; Statistical analysis; Studies; Vascular Stiffness; Velocity
• ISSN: 1720-8319; 1594-0667; 1720-8319
• DOI: 10.1007/s40520-019-01274-8

Background and aims This study aimed to investigate the association between cumulative C-reactive protein (cumCPR) and arterial stiffness. Methods The cross-sectional study included 15,432 participants from the Kailuan Cohort. The participants were divided into four groups according to cumCRP quartiles. The average brachial–ankle pulse wave velocity (baPWV) and detective rate of increased arterial stiffness were compared between exposure groups. Statistical analysis was performed with multiple logistic regression analysis to estimate the association between cumCRP and arterial stiffness by calculating the odds ratios (ORs) and 95% confidence intervals (CIs). The several sensitivity analyses were performed to test the robustness of our findings. Results The average baPWV increased from 1425.70 cm/s of Q1 group to 1626.48 cm/s of Q4 group. And the detective rate of arterial stiffness increased from 44.7 to 70.1% ( P