MMRdb: Measles, mumps, and rubella viruses database and analysis resource

• Published in: Infection, genetics and evolution genetics and evolution, 2019-11, Vol.75, p.103982-103982, Article 103982
• Main Authors: Almansour, Iman, Alhagri, Mazen
• Format: Article
• Language: English
• Subjects: Antigens, Viral - immunology; Databases, Factual; Genetic Variation; Genome, Viral; Humans; Measles; Measles-Mumps-Rubella Vaccine - genetics; Measles-Mumps-Rubella Vaccine - immunology; MMR; Morbillivirus - genetics; Morbillivirus - immunology; Mumps; Mumps virus - genetics; Mumps virus - immunology; Rubella; Rubella virus - genetics; Rubella virus - immunology; Sequence Analysis, RNA; User-Computer Interface
• ISSN: 1567-1348; 1567-7257
• DOI: 10.1016/j.meegid.2019.103982

Measles, mumps, and rubella viruses are well known human pathogens that cause mild to severe illnesses. Despite the existence of MMR vaccines since 1971, outbreaks have been largely documented even in highly vaccinated populations. There is a pressing need to develop a resource to monitor genetic and antigenic variations among these viruses. Here, we introduced MMRdb, a web central database and analysis resource for measles, mumps, and rubella viruses. Users can search viruses at gene level and obtain sequence information based on gene product, geographic location, year, or host. The MMRdb also catalogs experimentally verified B cells and T cells antigenic epitopes data. A set of computation tools such as multiple sequence alignment, Geo Chart, and sequence similarity BLAST search has been implemented in a user-friendly database. The main features of this database will assist researchers in monitoring genetics and antigenic variations, tracking geographic spread with regards of sequence information, and facilitate the development of diagnostics, vaccines, and immunotherapeutics. Database URL: http://mmrdb.org •A specialized genomic and protein database for Measles, Mumps, and Rubella Viruses.•Experimentally verified T cell and B cell antigenic epitopes to investigate patterns and conservations of antigenic epitopes.•User-friendly interface MMRdb is subcategorized into gene product, host, year, and geographic location.•Implementation of standalone tools, such as Clustal-Omega, Blast searches, Geo Map to perform genomic and protein analyses and track the origin of new virus strains.