Key production parameters for the development of solid lipid nanoparticles by high shear homogenization

In this work, we report the development and optimization of solid lipid nanoparticles (SLN) production by a simple, fast, and cost-effective high shear homogenization process. A screening of several solid lipids (Compritol 888 ATO, Precirol ATO 5, Cetyl Palmitate, Dynasan 118, Imwitor 900K, Stearic...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2019-10, Vol.24 (9), p.1181-1185
Main Authors: Souto, Eliana B., Doktorovova, Slavomira, Zielinska, Aleksandra, Silva, Amélia M.
Format: Article
Language:English
Subjects:
cetyl trimethylammonium bromide
Diglycerides - chemistry
Drug Carriers - chemistry
Drug Compounding
Fatty Acids - chemistry
high shear homogenization
Lipids - chemistry
Nanoparticles - chemistry
Palmitates - chemistry
Particle Size
Poloxamer - chemistry
rotor
Science & Technology
Solid lipid nanoparticles
stator
Stearic Acids - chemistry
Surface-Active Agents - chemistry
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Summary:In this work, we report the development and optimization of solid lipid nanoparticles (SLN) production by a simple, fast, and cost-effective high shear homogenization process. A screening of several solid lipids (Compritol 888 ATO, Precirol ATO 5, Cetyl Palmitate, Dynasan 118, Imwitor 900K, Stearic acid) has been carried out in combination with Poloxamer 188 as the selected surfactant, based on the mean particle size and polydispersity index. The improvement of the physical stability of the SLN dispersions was achieved by the use of a cationic lipid (cetyl trimethylammonium bromide) reaching zeta potential values above +60 mV. Combining the optimized speed and time of shear, monodispersed SLN (PdI < 0.25) under the nanometer range could be produced. The authors also wish to acknowledge Fundação para a Ciência e Tecnologia (FCT, Portugal) under the reference SFRH/BD/60552/2009. This work was also financed through the projects M-ERA-NET-0004/2015-PAIRED and UID/AGR/04033/2019, receiving support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450.2019.1647235