Intraosseous xanthoma of the mandible: A multi‐institutional case series with a literature review

Background The aim of the present study was to report the clinicopathologic, radiographic and immunohistochemical features of five South American cases of intraosseous xanthomas of the mandible and to compare them to those detected in a literature review. Methods Clinical data were collected from th...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2019-11, Vol.48 (10), p.935-942
Main Authors: de Arruda, José Alcides Almeida, Almeida, Tatiana Fernandes Araújo, Abreu, Lucas Guimarães, do Amaral, Márcio Bruno Figueiredo, Anbinder, Ana Lia, Flores, René Martínez, Agostini, Michelle, Romañach, Mário José, Silva, Tarcília Aparecida, de Andrade, Bruno Augusto Benevenuto, Mesquita, Ricardo Alves
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bone Neoplasms - diagnosis
Curettage
Dentistry
Female
Humans
Immunohistochemistry
intraosseous
jaw
Literature reviews
Male
Mandible
Mandible - pathology
Maxillofacial
Middle Aged
Xanthoma
xanthomatosis
Xanthomatosis - diagnosis
Young Adult
Young adults
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Summary:Background The aim of the present study was to report the clinicopathologic, radiographic and immunohistochemical features of five South American cases of intraosseous xanthomas of the mandible and to compare them to those detected in a literature review. Methods Clinical data were collected from the records of three Oral and Maxillofacial Pathology services in South America and compared with those compiled from a literature review based on a search of three electronic databases (PubMed, Web of Science and Scopus). All cases were evaluated by haematoxylin and eosin staining and immunohistochemistry for CD68 and S‐100. Results The series comprised four females (80%) and one male (20%) with a mean age of 23.3 ± 10.9 years (range: 13‐45 years). In four cases, there was involvement of the posterior region of the mandible (80%). The lesions presented radiographically as unilocular (60%) radiolucencies with punched‐out margin (80%). All cases predominantly consisted of CD68‐positive and S‐100‐negative xanthomatous cells. No recurrences were observed after curettage, with a median follow‐up of 27 months. Conclusion Intraosseous xanthoma of the jaws is a rare benign disorder. We report here five additional cases affecting the mandible, for a total of 36 cases of the jaws reported in the literature. Overall, this lesion has predilection for posterior sites of the mandible of asymptomatic young adults.
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.12940