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Repression of metastasis‐associated protein 2 for inhibiting metastasis of human oral cancer cells by promoting the p‐cofilin‐1/ LC3‐II expression

Background The overexpression of metastasis‐associated protein 2 (MTA2) contributes to human tumor progression and metastasis in various tumor cells. However, the role of MTA2 in human oral cancer progression remains unknown. Materials and methods MTA2 expression in human oral tumor tissues and cell...

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Published in:Journal of oral pathology & medicine 2019-11, Vol.48 (10), p.959-966
Main Authors: Tseng, Tsai‐Yi, Chiou, Hui‐Ling, Lin, Chiao‐Wen, Chen, Yong‐Syuan, Hsu, Li‐Sung, Lee, Chien‐Hsing, Hsieh, Yi‐Hsien
Format: Article
Language:English
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Summary:Background The overexpression of metastasis‐associated protein 2 (MTA2) contributes to human tumor progression and metastasis in various tumor cells. However, the role of MTA2 in human oral cancer progression remains unknown. Materials and methods MTA2 expression in human oral tumor tissues and cell lines was measured by immunohistochemistry and Western blotting. Cell proliferation and cell cycle were analyzed using MTT assay and flow cytometry. The effects of MTA2 on oral cell migration and invasion were investigated using migration and invasion assays. The expression of MTA2, p‐cofilin‐1, and MTA2‐induced LC3‐II levels were measured using Western blotting and an immunofluorescence assay. Results Based on the human oral cancer tissue array and TCGA database, we found that MTA2 was increased in oral cancer tissues than in non‐tumor oral tissues (P 
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.12941