New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

• Published in: Nature human behaviour 2019-09, Vol.3 (9), p.950-961
• Main Authors: Evangelou, Evangelos, Gao, He, Chu, Congying, Ntritsos, Georgios, Blakeley, Paul, Butts, Andrew R., Pazoki, Raha, Suzuki, Hideaki, Koskeridis, Fotios, Yiorkas, Andrianos M., Karaman, Ibrahim, Elliott, Joshua, Luo, Qiang, Aeschbacher, Stefanie, Bartz, Traci M., Baumeister, Sebastian E., Braund, Peter S., Brown, Michael R., Brody, Jennifer A., Clarke, Toni-Kim, Dimou, Niki, Faul, Jessica D., Homuth, Georg, Jackson, Anne U., Kentistou, Katherine A., Joshi, Peter K., Lemaitre, Rozenn N., Lind, Penelope A., Lyytikäinen, Leo-Pekka, Mangino, Massimo, Milaneschi, Yuri, Nelson, Christopher P., Nolte, Ilja M., Perälä, Mia-Maria, Polasek, Ozren, Porteous, David, Ratliff, Scott M., Smith, Jennifer A., Stančáková, Alena, Teumer, Alexander, Tuominen, Samuli, Thériault, Sébastien, Vangipurapu, Jagadish, Whitfield, John B., Wood, Alexis, Yao, Jie, Yu, Bing, Zhao, Wei, Arking, Dan E., Auvinen, Juha, Liu, Chunyu, Männikkö, Minna, Risch, Lorenz, Rotter, Jerome I., Snieder, Harold, Veijola, Juha, Blakemore, Alexandra I., Boehnke, Michael, Campbell, Harry, Conen, David, Eriksson, Johan G., Grabe, Hans J., Guo, Xiuqing, van der Harst, Pim, Hartman, Catharina A., Hayward, Caroline, Heath, Andrew C., Jarvelin, Marjo-Riitta, Kähönen, Mika, Kardia, Sharon L. R., Kühne, Michael, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lehtimäki, Terho, McIntosh, Andrew M., Mohlke, Karen L., Morrison, Alanna C., Martin, Nicholas G., Oldehinkel, Albertine J., Penninx, Brenda W. J. H., Psaty, Bruce M., Raitakari, Olli T., Rudan, Igor, Samani, Nilesh J., Scott, Laura J., Spector, Tim D., Verweij, Niek, Weir, David R., Wilson, James F., Levy, Daniel, Tzoulaki, Ioanna, Bell, Jimmy D., Matthews, Paul M., Rothenfluh, Adrian, Desrivières, Sylvane, Schumann, Gunter, Elliott, Paul
• Format: Article
• Language: English
• Subjects: 38/43; 45/43; 631/208; 64/24; 692/499; Adult; Aged; Alcohol Drinking - genetics; Alcohol related disorders; Alcohol use; Alcoholism - genetics; Behavioral Sciences; Biomedical and Life Sciences; Brain - physiopathology; Disability; Epidemiology; Experimental Psychology; Female; Functional magnetic resonance imaging; Gene expression; Genes; Genes - genetics; Genes - physiology; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study; Genomes; Genomics; Humans; Life Sciences; Magnetic Resonance Imaging; Male; Mental Disorders - genetics; Meta-analysis; Microeconomics; Middle Aged; Neuroimaging; Neurosciences; Personality and Social Psychology; Polymorphism, Single Nucleotide - genetics; Quantitative Trait Loci - genetics; Schizophrenia; Schizophrenia - genetics; Systematic review; White People - genetics
• ISSN: 2397-3374; 2397-3374
• DOI: 10.1038/s41562-019-0653-z

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d −1 ) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia. A study of genetic associations identifies 46 new loci associated with alcohol consumption. By assessing their function and potential pleiotropy, the authors suggest genetic mechanisms that are shared with neuropsychiatric disorders, including schizophrenia.