Effect of Long-Term Intake of Dietary Titanium Dioxide Nanoparticles on Intestine Inflammation in Mice

Early stage exposure of foodborne substances, such as brightening agent titanium dioxide nanoparticles (TiO2 NPs), can cause long-term effects in adulthood. We aimed to explore the potential adverse effect of long-term dietary intake of TiO2 NPs. After feeding for 2–3 months from weaning, TiO2 NPs-e...

Full description

Saved in:
Bibliographic Details
Published in:Journal of agricultural and food chemistry 2019-08, Vol.67 (33), p.9382-9389
Main Authors: Mu, Wei, Wang, Yong, Huang, Chao, Fu, Yijing, Li, Jingquan, Wang, Hui, Jia, Xudong, Ba, Qian
Format: Article
Language:English
Subjects:
Animals
Bacteria - classification
Bacteria - drug effects
Bacteria - genetics
Bacteria - isolation & purification
Body Weight - drug effects
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
Female
Gastrointestinal Microbiome - drug effects
Intestines - drug effects
Intestines - immunology
Intestines - microbiology
Macrophages - drug effects
Macrophages - immunology
Mice
Mice, Inbred C57BL
Nanoparticles - metabolism
Nanoparticles - toxicity
T-Lymphocytes, Regulatory - drug effects
T-Lymphocytes, Regulatory - immunology
Time Factors
Titanium - metabolism
Titanium - toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Early stage exposure of foodborne substances, such as brightening agent titanium dioxide nanoparticles (TiO2 NPs), can cause long-term effects in adulthood. We aimed to explore the potential adverse effect of long-term dietary intake of TiO2 NPs. After feeding for 2–3 months from weaning, TiO2 NPs-exposed mice showed lower body weight and induced intestinal inflammation. However, this phenomenon was not observed in gut microbiota-removed mice. TiO2 NPs exposure rarely affected the diversity of microbial communities, but significantly decreased the abundance of several probiotic taxa including Bifidobacterium and Lactobacillus. Additionally, TiO2 NPs aggravated DSS-induced chronic colitis and immune response in vivo, and reduced the population of CD4+T cells, regulatory T cells, and macrophages in mesenteric lymph nodes. Therefore, dietary TiO2 NPs could interfere with the balance of immune system and dynamic of gut microbiome, which may result in low-grade intestinal inflammation and aggravated immunological response to external stimulus, thus introducing potential health risk.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.9b02391