The synergistic anti-tumor effect of schisandrin B and apatinib

The synergistic anti-tumor effect of schisandrin B (Sch.B) and apatinib was investigated in vitro. The CCK-8 assay revealed that Sch.B enhanced the inhibition of apatinib on cell proliferation by arresting cell cycle in G0/G1 phase. Sch.B also potentiated the suppression of apatinib on cell migratio...

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Bibliographic Details
Published in:Journal of asian natural products research 2020-09, Vol.22 (9), p.839-849
Main Authors: Li, Ya-Jing, Liu, Hong-Tao, Xue, Chao-Jun, Xing, Xiao-Qin, Dong, Song-Tao, Wang, Lin-Shan, Ding, Cong-Yang, Meng, Lu, Dong, Zhan-Jun
Format: Article
Language:English
Subjects:
Anticancer properties
Apatinib
Apoptosis
Bax protein
Caspase-9
Cell adhesion & migration
Cell cycle
Cell migration
Cell proliferation
Cholecystokinin
Flow cytometry
G1 phase
gastric cancer
Gelatinase B
schisandrin B
SGC-7901
synergism
Wound healing
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Summary:The synergistic anti-tumor effect of schisandrin B (Sch.B) and apatinib was investigated in vitro. The CCK-8 assay revealed that Sch.B enhanced the inhibition of apatinib on cell proliferation by arresting cell cycle in G0/G1 phase. Sch.B also potentiated the suppression of apatinib on cell migration and invasion, by means of wound-healing and transwell invasion assay. Flow cytometry results showed that Sch.B enhanced apoptosis induced by apatinib. The results were confirmed by western blot analysis of the proteins MMP-9, and Bax caspase-9, and -12. These results suggest that combining apatinib and Sch.B is an effective therapeutic strategy for preventing GC progression.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2019.1645131