A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism

Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate. This prospective randomized double-blind control trial evaluates the efficacy and safety using intranasal dexmedetomidine with and without buccal midazolam for sedation in children with autism...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2019-09, Vol.49 (9), p.3798-3806
Main Authors: Li, Bi Lian, Yuen, Vivian Man-ying, Zhang, Na, Zhang, Huan Huan, Huang, Jun Xiang, Yang, Si Yuan, Miller, Jeffery W., Song, Xing Rong
Format: Article
Language:English
Subjects:
Auditory brainstem responses
Autism
Autistic children
Behavioral Science and Psychology
Brain stem
Child and School Psychology
Children
Comparative analysis
Computed tomography
Computerization
Conscious sedation
Cooperation
Dexmedetomidine
Diagnostic Tests
Dosage and administration
Double-blind studies
Drug therapy
Drug Use
Efficacy
Medical examination
Methods
Midazolam
Narcotics
Nasal sprays
Neurosciences
Original Paper
Pediatric research
Pediatrics
Pervasive Developmental Disorders
Psychology
Public Health
Safety
Sedation
Sedative drugs
Sedatives
Tomography
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Summary:Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate. This prospective randomized double-blind control trial evaluates the efficacy and safety using intranasal dexmedetomidine with and without buccal midazolam for sedation in children with autism undergoing computerized tomography and/or auditory brainstem response test. The primary outcome is the proportion of children attaining satisfactory sedation. One hundred and thirty-six children received intranasal dexmedetomidine and 139 received intranasal dexmedetomidine with buccal midazolam for sedation. Combination of intranasal dexmedetomidine and buccal midazolam was associated with higher sedation success when compared to intranasal dexmedetomidine. Since intranasal and buccal sedatives required little cooperation this could be especially useful technique for children with autism or other behavioral conditions.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-019-04095-w