Synthesis of Carum Carvi essential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

Scientists are attempting to find novel methods to overcome cancers. Nanoemulsion systems as the novel drug delivery tools have been widely used in cancer therapy. In this study, the Carum Carvi oil nanoemulsions (CCONE) were prepared and its cytotoxic activity was studied on human colon cancer HT‐2...

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Bibliographic Details
Published in:Journal of food biochemistry 2019-08, Vol.43 (8), p.e12956-n/a
Main Authors: Khatamian, Niloufar, Homayouni Tabrizi, Masoud, Ardalan, Pouran, Yadamani, Samira, Darchini Maragheh, Atieh
Format: Article
Language:English
Subjects:
apoptosis inducer
Carum Carvi essential oil nanoemulsion
HT‐29 cells
human colon cancer
natural efficient anticancer
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Summary:Scientists are attempting to find novel methods to overcome cancers. Nanoemulsion systems as the novel drug delivery tools have been widely used in cancer therapy. In this study, the Carum Carvi oil nanoemulsions (CCONE) were prepared and its cytotoxic activity was studied on human colon cancer HT‐29 cells using MTT assay. Flow cytometry and Real‐time qPCR were triggered to evaluate the nanoemulsions' apoptotic properties. The results showed a significant negative association between the HT‐29 cancer cell viability and CCONE doses of treatments compared with Huvec normal cells (p value 
ISSN:0145-8884
1745-4514
DOI:10.1111/jfbc.12956