Inactivation of oral biofilms using visible light and water-filtered infrared A radiation and indocyanine green

To investigate the antimicrobial photodynamic therapy (aPDT) of visible light and water-filtered infrared A radiation in combination with indocyanine green (ICG) on planktonic oral microorganisms as well as on oral biofilm. The irradiation was conducted for 5 min in combination with ICG. Treatment w...

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Bibliographic Details
Published in:Future medicinal chemistry 2019-07, Vol.11 (14), p.1721-1739
Main Authors: Burchard, Thomas, Karygianni, Lamprini, Hellwig, Elmar, Follo, Marie, Wrbas, Thomas, Wittmer, Annette, Vach, Kirstin, Al-Ahmad, Ali
Format: Article
Language:English
Subjects:
Antibiotics
antimicrobial photodynamic therapy
aPDT
Bacteria
Biofilms
Chlorhexidine
Colonies
Dentistry
Endodontics
ICG
indocyanine green
Light emitting diodes
Microorganisms
Morphology
oral biofilm
Periodontitis
Photodynamic therapy
VIS+wIRA
visible light and water-filtered infrared A
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Summary:To investigate the antimicrobial photodynamic therapy (aPDT) of visible light and water-filtered infrared A radiation in combination with indocyanine green (ICG) on planktonic oral microorganisms as well as on oral biofilm. The irradiation was conducted for 5 min in combination with ICG. Treatment with chlorhexidine served as a positive control. The number of colony forming units and bacterial vitality were quantified. All tested bacterial strains and salivary bacteria were killed at a level of 3log The colony forming units of the initial mature oral biofilms were strongly reduced. The high bactericidal effect of aPDT was confirmed by live/dead staining. The aPDT using visible light and water-filtered infrared A radiation and ICG has the potential to treat periodontitis and peri-implantitis.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2018-0522