Functional MRI activation patterns of cerebellum in patients with epilepsy and brain tumors

Function of cerebellum in control and coordination of motor function has been well established for several years. Recent functional magnetic resonance imaging (MRI) studies reveal activation of cerebellum with memory, speech and language tasks. We hypothesize that during every function in the brain...

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Bibliographic Details
Published in:Clinical anatomy (New York, N.Y.) N.Y.), 2019-11, Vol.32 (8), p.1053-1060
Main Authors: Zacharia, T. Thomas, Eslinger, Paul J
Format: Article
Language:English
Subjects:
Brain
Brain cancer
Brain mapping
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - physiopathology
Brain tumors
Cerebellum
Cerebellum - diagnostic imaging
Cerebellum - physiopathology
Cognition - physiology
Cognitive ability
Epilepsy
Epilepsy - diagnostic imaging
Epilepsy - physiopathology
Functional magnetic resonance imaging
functional MRI
Functionals
Humans
Language
Magnetic Resonance Imaging
Medical imaging
Memory
Memory tasks
Motor task performance
Neuroimaging
NMR
Nuclear magnetic resonance
Resonance
Retrospective Studies
Sensorimotor integration
Sensory integration
Subgroups
Tumors
Visual tasks
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Summary:Function of cerebellum in control and coordination of motor function has been well established for several years. Recent functional magnetic resonance imaging (MRI) studies reveal activation of cerebellum with memory, speech and language tasks. We hypothesize that during every function in the brain signals are relayed to cerebellum. We seek to analyze cognitive, emotional and social functions of cerebellum in patients with brain tumors and epilepsy utilizing functional Magnetic Resonance Imaging. Fifty‐one consecutive adult patients who underwent functional MRI examination were retrospectively analyzed for various activation patterns involving cerebellum. The neuropsychological battery of tasks assessed motor, language, memory, visual and auditory functions. Cognitive ability of all participants was assessed by Montreal cognitive assessment (MOCA). Patterns were analyzed for specific lobes and locations in the cerebellum. We found that simultaneous cerebellar activation is a consistent finding with brain activation during every functional MRI task that we tested except visual task. The patterns of functional MRI cerebellar activation were similar in both patient subgroups and control subjects compared to previously described patterns in normal subjects. Clin. Anat. 32:1053–1060, 2019. © 2019 Wiley Periodicals, Inc.
ISSN:0897-3806
1098-2353
DOI:10.1002/ca.23439