AR variants: lost in translation to clinical practice?

The concept that resistance against androgen receptor (AR) signalling inhibitors is explained by AR variants (ARVs) has spread as a seductive meme. However, two problems have delayed the translation of these findings to clinical practice: the complexity of the mechanism of action and the challenging...

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Bibliographic Details
Published in:Nature reviews. Urology 2019-08, Vol.16 (8), p.451-452
Main Authors: Handle, Florian, Claessens, Frank
Format: Article
Language:English
Subjects:
631/45/612/388
631/80/86/2363
692/699/67/1857
692/699/67/589/466
Clinical medicine
Development and progression
Drug Resistance, Neoplasm
Gene expression
Genetic aspects
Genetic variation
Health aspects
Humans
Male
Medicine
Medicine & Public Health
Messenger RNA
News & Views
news-and-views
Prostate cancer
Prostatic Neoplasms - chemistry
Prostatic Neoplasms - drug therapy
Receptors, Androgen - analysis
Receptors, Androgen - physiology
Urology
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Summary:The concept that resistance against androgen receptor (AR) signalling inhibitors is explained by AR variants (ARVs) has spread as a seductive meme. However, two problems have delayed the translation of these findings to clinical practice: the complexity of the mechanism of action and the challenging development of clinical decision-making tools involving ARVs.
ISSN:1759-4812
1759-4820
DOI:10.1038/s41585-019-0204-4