Pretreatment blood biomarkers predict pathologic responses to neo-CRT in patients with locally advanced rectal cancer

To evaluate the value of pretreatment blood biomarkers in predicting pathologic responses to neoadjuvant chemoradiotherapy (neo-CRT) in patients with locally advanced rectal cancer. We conducted logistic regression analysis and receiver operating characteristic to assess the predictive value of bloo...

Full description

Saved in:
Bibliographic Details
Published in:Future oncology (London, England) England), 2019-10, Vol.15 (28), p.3233-3242
Main Authors: Li, Aijie, He, Kewen, Guo, Dong, Liu, Chao, Wang, Duoying, Mu, Xiangkui, Yu, Jinming
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers
Biomarkers, Tumor - analysis
Blood diseases
Blood platelets
Cancer therapies
Capecitabine - administration & dosage
carcinoembryonic antigen
Carcinoembryonic Antigen - metabolism
Chemoradiotherapy - mortality
Chemotherapy
Colorectal cancer
DNA methylation
Female
Fluorouracil - administration & dosage
Follow-Up Studies
Gene expression
GPI-Linked Proteins - metabolism
Hospitals
Humans
Inflammation
Laboratories
Leucovorin - administration & dosage
Lymphatic system
lymphocyte-to-monocyte ratio
Lymphocytes
Lymphocytes - pathology
Male
Metastasis
Middle Aged
neoadjuvant chemoradiotherapy
Neoadjuvant Therapy - mortality
neutrophil-to-lymphocyte ratio
Neutrophils
Neutrophils - pathology
Oxaliplatin - administration & dosage
pathologic response
Patients
platelet-to-lymphocyte ratio
predictor
Prognosis
Radiation therapy
rectal cancer
Rectal Neoplasms - blood
Rectal Neoplasms - metabolism
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Retrospective Studies
ROC Curve
Surgery
Survival Rate
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the value of pretreatment blood biomarkers in predicting pathologic responses to neoadjuvant chemoradiotherapy (neo-CRT) in patients with locally advanced rectal cancer. We conducted logistic regression analysis and receiver operating characteristic to assess the predictive value of blood biomarkers. The outcome was defined by the pathologic complete response and good response. Carcinoembryonic antigen (CEA) (p 
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2019-0389