Synthesis of Nanoparticles of ZnS:Ag-L-cysteine-protoporphyrin IX Conjugates and Investigation its Potential of Reactive Oxygen Species Production

In this paper, L-cysteine capped Ag doped ZnS nanoparticles (NPs) were synthesized and its usage in photodynamic therapy was examined. Also, the details of the conjugation method for prepared NPs with sensitizer of protoporphyrin IX (PpIX) were reported. FT-IR studies indicate the formation of ZnS:A...

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Bibliographic Details
Published in:Journal of fluorescence 2019-09, Vol.29 (5), p.1089-1101
Main Authors: Sadeghi, E., Mahmoodian, Z., Zahedifar, M.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedicine
Biophysics
Biotechnology
Conjugates
Conjugation
Cysteine
Cysteine - chemistry
Energy Transfer
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Free radicals
Infrared analysis
Molecular Structure
Nanoparticles
Nanoparticles - chemistry
Organic chemistry
Original Article
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
Protoporphyrins - chemistry
Reactive Oxygen Species - analysis
Reactive Oxygen Species - metabolism
Silver
Silver - chemistry
Singlet oxygen
Sulfides - chemistry
Zinc Compounds - chemistry
Zinc sulfide
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Summary:In this paper, L-cysteine capped Ag doped ZnS nanoparticles (NPs) were synthesized and its usage in photodynamic therapy was examined. Also, the details of the conjugation method for prepared NPs with sensitizer of protoporphyrin IX (PpIX) were reported. FT-IR studies indicate the formation of ZnS:Ag nanoparticles capped with L-cysteine and an amide-bond formation between PpIX and L-cysteine-capped ZnS:Ag NPs. The formation of ZnS:Ag NPs conjugated to protoporphyrin IX was confirmed through the use of SEM, TEM, UV-Visible, FT-IR and DLS analysis. The efficient energy transfer from ZnS:Ag to PpIX sensitizer was estimated at about 90%. The production of reactive oxygen species, including singlet oxygen and free radicals, from ZnS:Ag NPs conjugated to protoporphyrin IX, was observed using a chemical method. The production of reactive oxygen species of this conjugate indicates its potential application in photodynamic therapy.
ISSN:1053-0509
1573-4994
DOI:10.1007/s10895-019-02420-1